Cocchetti Carlotta, Ristori Jiska, Romani Alessia, Maggi Mario, Fisher Alessandra Daphne
Andrology, Women's Endocrinology and Gender Incongruence Unit, Florence University Hospital, 50139 Florence, Italy.
Department of Experimental, Clinical and Biomedical Sciences, Careggi University Hospital, 50139 Florence, Italy.
J Clin Med. 2020 May 26;9(6):1609. doi: 10.3390/jcm9061609.
To date no standardized hormonal treatment protocols for non-binary transgender individuals have been described in the literature and there is a lack of data regarding their efficacy and safety.
To suggest possible treatment strategies for non-binary transgender individuals with non-standardized requests and to emphasize the importance of a personalized clinical approach.
A narrative review of pertinent literature on gender-affirming hormonal treatment in transgender persons was performed using PubMed.
New hormonal treatment regimens outside those reported in current guidelines should be considered for non-binary transgender individuals, in order to improve psychological well-being and quality of life. In the present review we suggested the use of hormonal and non-hormonal compounds, which-based on their mechanism of action-could be used in these cases depending on clients' requests.
Requests for an individualized hormonal treatment in non-binary transgender individuals represent a future challenge for professionals managing transgender health care. For each case, clinicians should balance the benefits and risks of a personalized non-standardized treatment, actively involving the person in decisions regarding hormonal treatment.
迄今为止，文献中尚未描述针对非二元跨性别者的标准化激素治疗方案，且缺乏关于其疗效和安全性的数据。
为有非标准化需求的非二元跨性别者提出可能的治疗策略，并强调个性化临床方法的重要性。
使用PubMed对关于跨性别者性别确认激素治疗的相关文献进行叙述性综述。
对于非二元跨性别者，应考虑现行指南中未报道的新激素治疗方案，以改善心理健康和生活质量。在本综述中，我们建议使用激素和非激素化合物，根据其作用机制，可根据患者需求用于这些情况。
非二元跨性别者对个性化激素治疗的需求对管理跨性别者医疗保健的专业人员来说是未来的一项挑战。对于每个病例，临床医生应权衡个性化非标准化治疗的益处和风险，积极让患者参与激素治疗的决策。
