Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA; Interdisciplinary Program in Bioengineering, Georgia Institute of Technology, Atlanta, GA, USA.
Trends Cancer. 2020 Oct;6(10):813-818. doi: 10.1016/j.trecan.2020.05.003. Epub 2020 May 25.
Multiplex spatial analyses dissect the heterogeneous cellular abundances and interactions in tumors. Single-cell bioimaging profiles many disease-associated protein biomarkers in patient biopsies to inform the design of cancer therapies. Guided by the mechanistic insights from spatial cellular maps, combination therapy can efficiently eliminate cancers with reduced off-targets, resistance, and relapse.
多重空间分析剖析了肿瘤中异质细胞丰度和相互作用。单细胞生物成像技术在患者活检中分析了许多与疾病相关的蛋白质生物标志物，为癌症治疗方案的设计提供信息。在空间细胞图谱提供的机制见解的指导下，联合治疗可以有效地消除癌症，减少脱靶、耐药和复发。
