Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Breast Cancer. 2021 Jul;28(4):777-791. doi: 10.1007/s12282-021-01237-w. Epub 2021 Mar 15.
Intricacy in treatment and diagnosis of breast cancer has been an obstacle due to genotype and phenotype heterogeneity. Understanding of non-genetic heterogeneity mechanisms along with considering role of genetic heterogeneity may fill the gaps in landscape painting of heterogeneity. The main factors contribute to non-genetic heterogeneity including: transcriptional pulsing/bursting or discontinuous transcriptions, stochastic partitioning of components at cell division and various signal transduction from tumor ecosystem. Throughout this review, we desired to provide a conceptual framework focused on non-genetic heterogeneity, which has been intended to offer insight into prediction, diagnosis and treatment of breast cancer.
由于基因型和表型异质性，乳腺癌的治疗和诊断的复杂性一直是一个障碍。了解非遗传异质性机制以及考虑遗传异质性的作用可能会填补异质性景观图中的空白。导致非遗传异质性的主要因素包括：转录脉冲/爆发或不连续转录、细胞分裂时组件的随机分配以及来自肿瘤生态系统的各种信号转导。在本综述中，我们旨在提供一个关注非遗传异质性的概念框架，旨在为乳腺癌的预测、诊断和治疗提供深入了解。
