Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, 20892-4370, USA
Development. 2020 May 28;147(10):dev175596. doi: 10.1242/dev.175596.
As the crucial non-cellular component of tissues, the extracellular matrix (ECM) provides both physical support and signaling regulation to cells. Some ECM molecules provide a fibrillar environment around cells, while others provide a sheet-like basement membrane scaffold beneath epithelial cells. In this Review, we focus on recent studies investigating the mechanical, biophysical and signaling cues provided to developing tissues by different types of ECM in a variety of developing organisms. In addition, we discuss how the ECM helps to regulate tissue morphology during embryonic development by governing key elements of cell shape, adhesion, migration and differentiation.
作为组织中至关重要的非细胞成分，细胞外基质 (ECM) 为细胞提供物理支撑和信号调节。一些 ECM 分子在细胞周围提供纤维状环境，而另一些则在上皮细胞下方提供片状基底膜支架。在这篇综述中，我们重点介绍了最近的研究，这些研究调查了不同类型的 ECM 在各种发育生物体中为发育组织提供的机械、生物物理和信号线索。此外，我们还讨论了 ECM 如何通过控制细胞形状、黏附、迁移和分化的关键要素来调节胚胎发育过程中的组织形态。
