CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, China.
Department of Chemistry, Tsinghua University, Beijing, 100084, China.
Acta Pharmacol Sin. 2020 Jul;41(7):895-901. doi: 10.1038/s41401-020-0423-5. Epub 2020 May 28.
Immunotherapy that activates the host immune system to reverse immunosuppression has emerged as a new generation of cancer treatment in both preclinical studies and clinical trials. Although immunotherapy has shown significant achievements in the treatment of various cancers, it faces challenges that limit its further evolution such as poor permeation and modest responsiveness. The development of nanoparticle drug delivery system has provided an opportunity to overcome these drawbacks and to achieve optimized immunotherapy. Based on the research of our group, we here introduce the new strategies being employed using nanoscale intelligent drug delivery systems to enhance the effects of cancer immunotherapy. We also provide a perspective on the further possible application of nanoparticles in more effective antitumor immunotherapy.
免疫疗法通过激活宿主免疫系统来逆转免疫抑制，已成为临床前研究和临床试验中新一代的癌症治疗方法。虽然免疫疗法在治疗各种癌症方面已经取得了显著的成就，但它也面临着一些限制其进一步发展的挑战，如渗透性差和反应性适度。纳米药物递送系统的发展为克服这些缺点和实现优化的免疫治疗提供了机会。基于我们小组的研究，我们在这里介绍了使用纳米级智能药物递送系统来增强癌症免疫治疗效果的新策略。我们还对纳米颗粒在更有效的抗肿瘤免疫治疗中的进一步可能应用提供了一些看法。
