Al-Hatmi A M S, Sandoval-Denis M, Nabet C, Ahmed S A, Demar M, Normand A-C, de Hoog G S
Westerdijk Fungal Biodiversity Institute, P.O. Box 85167, 3508 AD Utrecht, The Netherlands.
Foundation Atlas of Clinical Fungi, Hilversum, The Netherlands.
Fungal Syst Evol. 2019 Dec;4:171-181. doi: 10.3114/fuse.2019.04.09. Epub 2019 Jun 25.
We describe the isolation and characterization of from a bronchoalveolar lavage (BAL) sample of a female patient living in French Guiana with underlying pulmonary infections. Phylogenetic analysis of fragments of the calmodulin (), translation elongation factor (), RNA polymerase second largest subunit (), and β-tubulin () loci revealed that strain CBS 143874 was closely related to isolate NRRL 25615, a known but undescribed phylogenetic species belonging to the African clade of the species complex. The fungus differed phylogenetically and morphologically from related known species, and is therefore described as the new taxon . Antifungal susceptibility testing suggested that the new species is resistant to echinocandins, fluconazole, itraconazole with lower MICs against amphotericin B, voriconazole and posaconazole.
我们描述了从法属圭亚那一名患有潜在肺部感染的女性患者的支气管肺泡灌洗（BAL）样本中分离和鉴定[具体真菌名称未给出]的过程。对钙调蛋白（）、翻译延伸因子（）、RNA聚合酶第二大亚基（）和β-微管蛋白（）基因座片段进行的系统发育分析表明，CBS 143874菌株与分离株NRRL 25615密切相关，NRRL 25615是属于[真菌物种名称未给出]物种复合体非洲分支的一个已知但未描述的系统发育物种。该真菌在系统发育和形态上与相关已知物种不同，因此被描述为新分类单元[新物种名称未给出]。抗真菌药敏试验表明，该新物种对棘白菌素、氟康唑、伊曲康唑耐药，对两性霉素B、伏立康唑和泊沙康唑的最低抑菌浓度较低。
