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缺氧缺血性脑病新生儿外周血环状 RNA 的表达谱。

Expression profile of circular RNAs in the peripheral blood of neonates with hypoxic‑ischemic encephalopathy.

机构信息

Department of Pediatric, Jingjiang People's Hospital Affiliated to Yangzhou University, Jingjiang, Jiangsu 214500, P.R. China.

Department of Pediatrics, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210036, P.R. China.

出版信息

Mol Med Rep. 2020 Jul;22(1):87-96. doi: 10.3892/mmr.2020.11091. Epub 2020 Apr 23.

DOI:10.3892/mmr.2020.11091
PMID:32468058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7248490/
Abstract

Circular RNAs (circRNAs) are a class of non-coding RNAs that participate in various biological processes. However, the function of circRNAs in neonatal hypoxic‑ischemic encephalopathy (HIE) is not fully understood. In the present study, the differentially expressed circRNAs in the peripheral blood of neonates with HIE and control samples were characterized by a microarray assay. A total of 456 circRNAs were significantly differentially expressed in the peripheral blood of neonates with HIE, with 250 upregulated and 206 downregulated circRNAs in HIE compared with the control samples. Reverse transcription‑quantitative PCR was used to investigate specific circRNAs. Gene Ontology, and Kyoto Encyclopedia of Genes and Genomes pathway analyses were used to determine the function of the parent genes of the dysregulated circRNAs. In addition, microRNAs that may be associated with specific circRNAs were predicted using miRanda. Collectively, the present results indicated the potential importance of circRNAs in the peripheral blood of neonates with HIE.

摘要

环状 RNA（circRNA）是一类参与多种生物学过程的非编码 RNA。然而，circRNA 在新生儿缺氧缺血性脑病（HIE）中的功能尚未完全阐明。在本研究中，通过微阵列分析对 HIE 新生儿和对照样本外周血中的差异表达 circRNA 进行了表征。与对照样本相比，HIE 新生儿外周血中共有 456 个 circRNA 显著差异表达，其中 250 个上调，206 个下调。逆转录-定量 PCR 用于研究特定的 circRNA。基因本体论和京都基因与基因组百科全书通路分析用于确定失调 circRNA 的亲本基因的功能。此外，使用 miRanda 预测可能与特定 circRNA 相关的 microRNA。综上所述，本研究结果表明 circRNA 在 HIE 新生儿外周血中具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8765/7248490/16642ea7bbc8/MMR-22-01-0087-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8765/7248490/88c6c0286c12/MMR-22-01-0087-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8765/7248490/768bc2f21c77/MMR-22-01-0087-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8765/7248490/03ffbacccfa2/MMR-22-01-0087-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8765/7248490/8c75dd80ee0a/MMR-22-01-0087-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8765/7248490/16642ea7bbc8/MMR-22-01-0087-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8765/7248490/88c6c0286c12/MMR-22-01-0087-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8765/7248490/768bc2f21c77/MMR-22-01-0087-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8765/7248490/03ffbacccfa2/MMR-22-01-0087-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8765/7248490/8c75dd80ee0a/MMR-22-01-0087-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8765/7248490/16642ea7bbc8/MMR-22-01-0087-g04.jpg

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