Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Centre for Healthy Brain Ageing, School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, Australia; Bioanalytical Mass Spectrometry Facility, University of New South Wales, Sydney, Australia; School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Alzheimers Dement. 2017 Jul;13(7):810-827. doi: 10.1016/j.jalz.2017.01.008. Epub 2017 Feb 24.
The brain is highly enriched in lipids, and an intensive study of these lipids may be informative, not only of normal brain function but also of changes with age and in disease. In recent years, the development of highly sensitive mass spectrometry platforms and other high-throughput technologies has enabled the discovery of complex changes in the entire lipidome. This lipidomics approach promises to be a particularly useful tool for identifying diagnostic biomarkers for early detection of age-related neurodegenerative disease, such as Alzheimer's disease (AD), which has till recently been limited to protein- and gene-centric approaches. This review highlights known lipid changes affecting the AD brain and presents an update on the progress of lipid biomarker research in AD. Important considerations for designing large-scale lipidomics experiments are discussed to help standardize findings across different laboratories, as well as challenges associated with moving toward clinical application.
大脑富含脂质，对这些脂质进行深入研究不仅可以提供有关正常大脑功能的信息，还可以提供与年龄和疾病相关的变化信息。近年来，高灵敏度质谱平台和其他高通量技术的发展使得整个脂质组的复杂变化得以发现。这种脂质组学方法有望成为识别诊断生物标志物的有用工具，以便早期发现与年龄相关的神经退行性疾病，如阿尔茨海默病（AD），而 AD 的诊断方法直到最近还局限于以蛋白质和基因为中心的方法。本文重点介绍了影响 AD 大脑的已知脂质变化，并介绍了 AD 中脂质生物标志物研究的最新进展。讨论了设计大规模脂质组学实验的重要注意事项，以帮助在不同实验室之间标准化发现，以及向临床应用推进所面临的挑战。
