帕夫塔瘦药花精油的化学成分和乙酰胆碱酯酶抑制活性。
Chemical composition and anticholinesterase inhibitory activity of Pavetta graciliflora Wall. ex Ridl. essential oil.
机构信息
Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris (UPSI), 35900 Tanjong Malim, Perak, Malaysia, Phone: +6015-48797123.
School of Environmental and Natural Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor, Malaysia.
出版信息
Z Naturforsch C J Biosci. 2020 Nov 26;75(11-12):467-471. doi: 10.1515/znc-2020-0075.
Chemical composition and anticholinesterase activity of the essential oil of Pavetta graciliflora Wall. ex Ridl. (Rubiaceae) was examined for the first time. The essential oil was obtained by hydrodistillation and was fully characterized by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total of 20 components were identified in the essential oil, which made up 92.85% of the total oil. The essential oil is composed mainly of β-caryophyllene (42.52%), caryophyllene oxide (25.33%), β-pinene (8.67%), and α-pinene (6.52%). The essential oil showed weak inhibitory activity against acetylcholinesterase (AChE) (I%: 62.5%) and butyrylcholinesterase (BChE) (I%: 65.4%) assays. Our findings were shown to be very useful for the characterization, pharmaceutical, and therapeutic applications of the essential oil from P. graciliflora.
首次对白花丹（茜草科）精油的化学成分和乙酰胆碱酯酶抑制活性进行了研究。精油通过水蒸馏法获得，并通过气相色谱（GC）和气相色谱-质谱（GC-MS）进行了全面表征。在精油中鉴定出 20 种成分，占总油量的 92.85%。该精油主要由β-石竹烯（42.52%）、石竹烯氧化物（25.33%）、β-蒎烯（8.67%）和α-蒎烯（6.52%）组成。精油对乙酰胆碱酯酶（AChE）（I%：62.5%）和丁酰胆碱酯酶（BChE）（I%：65.4%）测定显示出较弱的抑制活性。我们的发现对于白花丹精油的特征描述、药物和治疗应用非常有用。
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