Preventive Dental Sciences Department, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Molecules. 2020 May 27;25(11):2495. doi: 10.3390/molecules25112495.
At present, bioactive glasses (BAGs) are demonstrating promising results in the remineralization of hard tissues. Their bioactive properties can potentially overcome the demineralization effect accompanying orthodontic treatment. This review aimed to evaluate the effectiveness of bioactive glass enhanced orthodontic bonding resins on enamel remineralization, in addition to their antibacterial, ion release and acid neutralization effect. Four databases (PubMed, MEDLINE, Web of Science and Scopus) were searched. Two hundred and fifty-one full-text articles were screened independently, out of which seven studies satisfied the inclusion criteria. Quality appraisal was performed by two independent reviewers. Methodologies used to assess the anti-demineralization effect included Micro-Computed Tomography, Polarized Light Microscopy and Hardness Testing (Knoop and Berkovich). All seven articles confirmed the superior remineralization effect of BAG orthodontic bonding resins compared to their non-BAG counterparts. A proportional relationship was proved between BAG concentrations and increased anti-demineralization effect. The addition of antibacterial agents to BAG does not necessarily improve its anti-demineralization effect. Although studies have confirmed the effectiveness of BAG orthodontic bonding resins on enamel remineralization, there was a degree of heterogeneity across studies due to the lack of an in vitro studies standardized protocol.
目前，生物活性玻璃（BAGs）在硬组织再矿化方面表现出良好的效果。其生物活性特性可能克服伴随正畸治疗的脱矿作用。本综述旨在评估生物活性玻璃增强型正畸粘接树脂对釉质再矿化的有效性，以及其抗菌、离子释放和酸中和作用。四个数据库（PubMed、MEDLINE、Web of Science 和 Scopus）进行了检索。独立筛选了 251 篇全文文章，其中 7 项研究符合纳入标准。两位独立评审员进行了质量评估。评估抗脱矿作用的方法包括微计算机断层扫描、偏光显微镜和硬度测试（Knoop 和 Berkovich）。所有 7 项研究均证实了 BAG 正畸粘接树脂比非 BAG 树脂具有更好的再矿化效果。BAG 浓度与增强的抗脱矿作用之间存在比例关系。向 BAG 添加抗菌剂不一定能提高其抗脱矿作用。尽管研究证实了 BAG 正畸粘接树脂对釉质再矿化的有效性，但由于缺乏标准化的体外研究方案，研究之间存在一定程度的异质性。
