Lee Seung-Min, Yoo Kyung-Hyeon, Yoon Seog-Young, Kim In-Ryoung, Park Bong-Soo, Son Woo-Sung, Ko Ching-Chang, Son Sung-Ae, Kim Yong-Il
Department of Orthodontics, Dental Research Institute, Pusan National University Dental Hospital, Yangsan 50612, Korea.
School of Materials Science and Engineering, Pusan National University, Busan 46241, Korea.
Materials (Basel). 2018 Sep 14;11(9):1728. doi: 10.3390/ma11091728.
White spot lesions (WSLs), a side effect of orthodontic treatment, can result in reversible and unaesthetic results. Graphene oxide (GO) with a bioactive glass (BAG) mixture (BAG@GO) was added to Low-Viscosity Transbond XT (LV) in a ratio of 1, 3, and 5%. The composite's characterization and its physical and biological properties were verified with scanning electron microscopy (SEM) and X-ray diffraction (XRD); its microhardness, shear bond strength (SBS), cell viability, and adhesive remnant index (ARI) were also assessed. Efficiency in reducing WSL was evaluated using antibacterial activity of . Anti-demineralization was analyzed using a cycle of the acid-base solution. Adhesives with 3 wt.% or 5 wt.% of BAG@GO showed significant increase in microhardness compared with LV. The sample and LV groups showed no significant differences in SBS or ARI. The cell viability test confirmed that none of the sample groups showed higher toxicity compared to the LV group. Antibacterial activity was higher in the 48-h group than in the 24 h group; the 48 h test showed that BAG@GO had a high antibacterial effect, which was more pronounced in 5 wt.% of BAG@GO. Anti-demineralization effect was higher in the BAG@GO-group than in the LV-group; the higher the BAG@GO concentration, the higher the anti-demineralization effect.
白斑病变（WSLs）是正畸治疗的一种副作用，会导致可逆且不美观的结果。将氧化石墨烯（GO）与生物活性玻璃（BAG）的混合物（BAG@GO）以1%、3%和5%的比例添加到低粘度Transbond XT（LV）中。通过扫描电子显微镜（SEM）和X射线衍射（XRD）对该复合材料的特性及其物理和生物学性能进行了验证；还评估了其显微硬度、剪切粘结强度（SBS）、细胞活力和粘结残留指数（ARI）。使用……的抗菌活性评估减少WSL的效率。使用酸碱溶液循环分析抗脱矿作用。与LV相比，含有3 wt.%或5 wt.% BAG@GO的粘合剂的显微硬度显著增加。样品组和LV组在SBS或ARI方面无显著差异。细胞活力测试证实，与LV组相比，没有一个样品组表现出更高的毒性。48小时组的抗菌活性高于24小时组；48小时测试表明，BAG@GO具有较高的抗菌效果，在5 wt.% BAG@GO中更为明显。BAG@GO组的抗脱矿作用高于LV组；BAG@GO浓度越高，抗脱矿作用越强。
