School of Pharmacy, Ningxia Medical University, Yinchuan, 750004, China.
School of Basic Medical Sciences, Ningxia Medical University, Yinchuan, 750004, China.
J Ethnopharmacol. 2020 Oct 5;260:112994. doi: 10.1016/j.jep.2020.112994. Epub 2020 May 27.
Cynanchum paniculatum (Bunge) Kitag. ex H. Hara (C. paniculatum), is a broadly used traditional medicinal plant by East Asians. The roots and rhizomes of this herb were named 'Xu-Chang-Qing' since the Qin or Han Dynasty (B.C.221-220) in China. It is pungent and warm in nature and associated with the liver and stomach meridians. Moreover, the efficacy of this herb are dispelling wind, resolving dampness, relieving pain and itching. It is used for treating the onset of rheumatic arthralgia, stomachache, toothache, lumbago, soft tissue injury, rubella and eczema.
The purpose of this paper is to provide a systematic review about the botany, traditional uses, phytochemistry and pharmacology of C. paniculatum on the strength of the studies in the past two decades.
A comprehensive search on previous literature was conducted on databases such as Web of Science, Pubmed, Sciencedirect, American Chemical Society (ACS), Google scholar and China national knowledge internet (CNKI). The search was based on the botany, traditional uses, phytochemistry and pharmacology of C. paniculatum. The key search words were 'Cynanchum paniculatum' and 'Radix Cynanchi Paniculati'. In addition, some published books were searched for more information on the herb.
Over 150 compounds have been isolated and identified from C. paniculatum, including C steroids, volatile oils, carbohydrates and phenanthroindolizidine alkaloids. Extensive pharmacological activities of the extracts or compounds of C. paniculatum in vivo and in vitro were confirmed including anti-inflammatory, anti-nociceptive, sedative antiviral, antitumor, neuroprotective, treating snake bites, immunomodulatory, anti-radiation, vasodilatory, acaricidal potentials and anti-adipogenic activities.
In this paper, the botany, traditional uses, phytochemistry and pharmacology of C. paniculatum were reviewed. This herb has long been used as traditional medicine. It was reported with numerous chemical ingredients and various pharmacological activities with anti-inflammatory, antitumor, neuroprotection, etc. In the future, C. paniculatum still needs further study, such as identifying the active compounds, clarifying the pharmacological mechanisms, discussing quality and safety.
徐长卿（Cynanchum paniculatum (Bunge) Kitag. ex H. Hara）是一种广泛应用于东亚传统医学的植物。自中国秦汉时期（公元前 221-220 年）以来，这种草药的根和根茎被命名为“徐长卿”。它的性质辛辣而温热，与肝、胃经络有关。此外，这种草药具有祛风、祛湿、止痛、止痒的功效。它用于治疗风湿性关节炎、胃痛、牙痛、腰痛、软组织损伤、风疹和湿疹的发作。
本文旨在对过去二十年来的研究进行系统综述，介绍徐长卿的植物学、传统用途、植物化学和药理学。
在 Web of Science、Pubmed、Sciencedirect、美国化学学会（ACS）、Google scholar 和中国国家知识互联网（CNKI）等数据库上对过去的文献进行了全面检索。检索基于徐长卿的植物学、传统用途、植物化学和药理学。主要搜索词为“Cynanchum paniculatum”和“Radix Cynanchi Paniculati”。此外，还查阅了一些已出版的书籍，以获取更多关于该草药的信息。
从徐长卿中分离鉴定出 150 多种化合物，包括 C 甾体、挥发油、碳水化合物和菲并吲哚里啶生物碱。证实了徐长卿提取物或化合物在体内和体外的广泛药理活性，包括抗炎、镇痛、镇静、抗病毒、抗肿瘤、神经保护、治疗蛇咬伤、免疫调节、抗辐射、血管扩张、杀虫潜力和抗脂肪生成活性。
本文综述了徐长卿的植物学、传统用途、植物化学和药理学。这种草药作为传统药物已有很长的历史。据报道，它含有多种化学成分，具有多种药理活性，如抗炎、抗肿瘤、神经保护等。在未来，徐长卿仍需要进一步研究，如鉴定活性化合物、阐明药理机制、讨论质量和安全性。
