J Phys Act Health. 2020 May 29;17(7):729-735. doi: 10.1123/jpah.2019-0461.
Previous observations regarding association between physical activity (PA) and use of medicines among older adults are derived from self-reported PA. This study aimed to evaluate the association between objectively measured PA and polypharmacy among older adults with multimorbidity in Southern Brazil.
This study included 875 noninstitutionalized older people, aged ≥60 years. Prescribed medicines used in the 15 days prior to the interview, socioeconomic data, and the presence of comorbidities were self-reported. Accelerometers were used to evaluate PA following the interview.
Prevalence of polypharmacy (≥5 medicines) was 38.3% (95% confidence interval, 35.0-41.5); those belonging to the lowest tertile of PA used more medicines. The authors observed a significant inverse association for polypharmacy between men belonging to the second and third tertiles of PA for objectively measured overall PA and light PA compared with the most inactive tertile. For women, the association between PA and polypharmacy was significant for overall, light, and moderate to vigorous PA only in the third tertile.
Overall, light and moderate to vigorous PA were inversely associated to polypharmacy and differed by gender. Promotion of PA in older adults may be an effective intervention to reduce the number of medicines used independent of the number of comorbidities.
先前关于体力活动（PA）与老年人用药之间关联的观察结果来自于自我报告的 PA。本研究旨在评估巴西南部患有多种疾病的老年人中，通过客观测量 PA 与多药治疗之间的关联。
本研究纳入了 875 名非住院老年人，年龄≥60 岁。自我报告了在访谈前 15 天内使用的处方药、社会经济数据以及合并症的存在情况。在访谈后使用加速度计评估 PA。
多药治疗（≥5 种药物）的患病率为 38.3%（95%置信区间，35.0-41.5）；PA 最低三分位组的老年人使用的药物更多。与最不活跃的三分位组相比，处于 PA 客观测量总 PA 和轻 PA 第二和第三三分位组的男性多药治疗的比例显著降低。对于女性，只有在第三三分位组，PA 与多药治疗之间存在显著关联，适用于总 PA、轻 PA 和中等到剧烈 PA。
总体而言，轻体力活动和中等到剧烈体力活动与多药治疗呈负相关，且与性别有关。促进老年人的 PA 可能是一种有效的干预措施，可以减少用药数量，而与合并症的数量无关。
