Malin Steven K, Heiston Emily M, Gilbertson Nicole M, Eichner Natalie Z M
Department of Kinesiology, University of Virginia, Charlottesville, VA, United States; Division of Endocrinology & Metabolism, University of Virginia, Charlottesville, VA, United States; Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA, United States.
Department of Kinesiology, University of Virginia, Charlottesville, VA, United States.
Physiol Behav. 2020 Sep 1;223:112978. doi: 10.1016/j.physbeh.2020.112978. Epub 2020 May 29.
Caloric restriction is suggested to increase hunger, in part, through complex interactions of hormones and behavior that contribute to challenges in long-term weight loss. Although intense exercise may attenuate appetite, no data exist testing the effects of interval exercise (INT) during a low-calorie diet (LCD) on appetite regulation. We hypothesized that LCD+INT would favorably influence satiety when compared with an energy-deficit matched LCD in women with obesity. Twenty-six women with obesity (47.3±2.4 yrs; 37.3 ± 1.2 kg/m) were randomized to either LCD (n = 13; mixed meals of ~1200 kcal/d) or LCD+INT (n = 13; 60 min/d of supervised interval exercise at 90% HRpeak for 3 min and 50% HRpeak for 3 min) for 2 weeks. An additional 350kcal (shake) was provided to LCD+INT individuals post-exercise to equate energy availability between groups. Total PYY, acylated ghrelin and des-ghrelin were measured at 0, 30 and 60 min of a 75g OGTT before and after the intervention. Visual analog scales were also administered at 0 and 120 min of the OGTT to assess appetite perception. Food logs were recorded prior to and during the intervention to ensure caloric intake compliance. Compared with pre-intervention conditions, both interventions decreased food intake (P = 0.001) and body fat (P < 0.01). There was no effect on fasting PYY, but both LCD and LCD+INT increased post-prandial PYY iAUC (P < 0.001) relative to pre-intervention. LCD+INT maintained fasting acylated ghrelin (P = 0.06) and suppressed post-prandial acylated ghrelin iAUC (P = 0.04) compared to LCD. Neither intervention impacted circulating des- ghrelin before or following the OGTT. Interestingly, LCD+INT attenuated fasting hunger and maintained fullness compared with LCD (P = 0.05 and P = 0.06, respectively). Taken together, interval exercise favors acylated ghrelin suppression and perception of hunger during a LCD in women with obesity.
热量限制被认为会增加饥饿感，部分原因是激素和行为之间的复杂相互作用，这些相互作用导致了长期减肥面临挑战。尽管高强度运动可能会减弱食欲，但尚无数据测试低热量饮食（LCD）期间间歇运动（INT）对食欲调节的影响。我们假设，与能量不足匹配的LCD相比，LCD+INT对肥胖女性的饱腹感有积极影响。26名肥胖女性（47.3±2.4岁；37.3±1.2kg/m）被随机分为LCD组（n=13；每日混合餐约1200千卡）或LCD+INT组（n=13；每天在监督下进行60分钟间歇运动，90%心率峰值持续3分钟，50%心率峰值持续3分钟），为期2周。运动后向LCD+INT组个体额外提供350千卡（奶昔），以使两组之间的能量供应相等。在干预前后，于75克口服葡萄糖耐量试验（OGTT）的0、30和60分钟测量总肽YY、酰化胃饥饿素和去酰化胃饥饿素。在OGTT的0和120分钟时也使用视觉模拟量表来评估食欲感知。在干预前和干预期间记录食物日志，以确保热量摄入符合要求。与干预前相比，两种干预均减少了食物摄入量（P=0.001）和体脂（P<0.01）。对空腹肽YY没有影响，但与干预前相比，LCD和LCD+INT均增加了餐后肽YY的增量曲线下面积（P<0.001）。与LCD相比，LCD+INT维持了空腹酰化胃饥饿素水平（P=0.06），并抑制了餐后酰化胃饥饿素的增量曲线下面积（P=0.04）。两种干预在OGTT前后均未影响循环中的去酰化胃饥饿素。有趣的是，与LCD相比，LCD+INT减轻了空腹饥饿感并维持了饱腹感（分别为P=0.05和P=0.06）。综上所述，间歇运动有利于在肥胖女性的低热量饮食期间抑制酰化胃饥饿素并改善饥饿感。
