Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, PR China.
Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Pharmacol Ther. 2020 Sep;213:107591. doi: 10.1016/j.pharmthera.2020.107591. Epub 2020 May 29.
Long noncoding RNAs (lncRNAs) have multiple functions in the regulation of cellular homeostasis. In recent years, numerous studies have shown that tumor-associated lncRNAs play key roles in promoting and maintaining tumor initiation and progression by shaping the tumor microenvironment through changing tumor cell intrinsic properties. Here, we focus on the roles of lncRNAs in cancer immunology. In the first part, we provide an overview of the roles played by lncRNAs and their deregulation in cancer at the cancer cell- and tumor microenvironment-associated immune cell levels. We go on to describe preclinical strategies for targeting lncRNAs, particularly highlighting the effects on tumor microenvironments. We then discuss the possibility of combining lncRNA targeting and tumor immune checkpoint inhibitor antibodies to treat cancer.
长链非编码 RNA（lncRNAs）在细胞内稳态的调节中具有多种功能。近年来，大量研究表明，肿瘤相关 lncRNAs 通过改变肿瘤细胞内在特性来塑造肿瘤微环境，在促进和维持肿瘤起始和进展方面发挥着关键作用。在这里，我们重点关注 lncRNAs 在癌症免疫学中的作用。在第一部分中，我们概述了 lncRNAs 在癌症中的作用及其在肿瘤细胞和肿瘤微环境相关免疫细胞水平上的失调。我们接着描述了靶向 lncRNAs 的临床前策略，特别强调了对肿瘤微环境的影响。然后，我们讨论了将 lncRNA 靶向与肿瘤免疫检查点抑制剂抗体联合治疗癌症的可能性。
