AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, France; INSERM U894, Centre for Psychiatry and Neurosciences, 102-108 rue de la Santé, 75014, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Faculty of Medicine, Paris, France.
AP-HP, Department of Psychiatry, Louis Mourier Hospital, Colombes, France; INSERM U894, Centre for Psychiatry and Neurosciences, 102-108 rue de la Santé, 75014, Paris, France; Univ Paris Diderot, Sorbonne Paris Cite, Faculty of Medicine, Paris, France.
Psychiatry Res. 2020 Aug;290:113101. doi: 10.1016/j.psychres.2020.113101. Epub 2020 May 23.
A traumatic life experience in childhood is a fundamental risk factor of numerous psychiatric disorders. Recently, studies try to evaluate the mental health consequences on victims' offspring, but few psychiatric disorders were examined, and whether these results apply to the general population remains unknown. In this study, we use the National Epidemiologic Survey on Alcohol and Related Conditions, a large representative sample of American population, in order to estimate the impact on the offspring of a traumatic experience in parents. Besides, we use a well-known risk factor for offspring's psychiatric disorder: a familial history of a psychiatric disorder, in order to compare and assess the importance of parental traumatism as a risk factor for the offspring. Our results show that the five psychiatric disorders studied, alcohol use disorder, substance use disorder, mood disorder, antisocial personality disorder and anxiety disorder, are more prevalent in the offspring, when at least one parent report a traumatic life event in his own childhood. Moreover, the magnitude of this risk factor is close to the magnitude of having a parental history of psychiatric disorder.
童年时期的创伤性生活经历是许多精神疾病的基本风险因素。最近，研究试图评估精神健康对受害者后代的影响，但很少有精神疾病得到研究，这些结果是否适用于一般人群尚不清楚。在这项研究中，我们使用了全国酒精和相关条件流行病学调查，这是美国人口的一个大型代表性样本，以评估父母经历创伤对后代的影响。此外，我们使用了一个众所周知的后代精神疾病风险因素：家族精神疾病史，以便比较和评估父母创伤作为后代风险因素的重要性。我们的研究结果表明，在至少有一位父母报告自己童年时期发生过创伤性生活事件的情况下，研究中所涉及的五种精神疾病，包括酒精使用障碍、物质使用障碍、情绪障碍、反社会人格障碍和焦虑障碍，在后代中更为普遍。此外，这种风险因素的程度与父母有精神疾病史的程度相当。
