Department of Surgery, School of Medicine, Cancer Center, University of Colorado, Anschutz Medical Campus, 12631 E. 17th Avenue, C-305, Aurora, CO, 80045, USA.
Surg Today. 2020 Oct;50(10):1117-1125. doi: 10.1007/s00595-020-02028-0. Epub 2020 May 30.
Remarkable progress has been made in treating pancreatic cancer over the past century, including refinement of our surgical techniques and improvements in adjuvant and neoadjuvant therapies. Despite these advances, the incidence of pancreatic cancer is rising globally, and it remains a deadly disease. In this review, we highlight the historical perspectives of pancreatic cancer treatment and outline the areas of future advancement that will assist progression towards better outcomes. Areas of future advancement include improving prevention strategies and early detection, refining our molecular understanding of pancreatic cancer, identifying more effective systemic therapies, and improving quality of life and surgical outcomes. Furthermore, systems need to be put in place to ensure all patients with pancreatic cancer receive high quality care and are given the appropriate options and sequence of therapy. This is best achieved through multidisciplinary care.
在过去的一个世纪中,在治疗胰腺癌方面取得了显著进展,包括我们的手术技术的改进和辅助及新辅助治疗的改善。尽管取得了这些进展,但全球范围内胰腺癌的发病率仍在上升,它仍然是一种致命的疾病。在这篇综述中,我们强调了胰腺癌治疗的历史观点,并概述了未来将有助于取得更好结果的进展领域。未来的进展领域包括改善预防策略和早期检测、深化我们对胰腺癌的分子认识、确定更有效的系统治疗方法以及提高生活质量和手术结果。此外,需要建立系统来确保所有胰腺癌患者都能获得高质量的护理,并为他们提供适当的治疗方案和治疗顺序。这最好通过多学科护理来实现。