Arizona Poison and Drug Information Center, University of Arizona Arizona Health Sciences Center, Tucson, AZ, USA.
Department of Emergency Medicine, University of Arizona College of Medicine, El Paso, TX, USA.
Clin Toxicol (Phila). 2021 Feb;59(2):169-171. doi: 10.1080/15563650.2020.1771360. Epub 2020 Jun 1.
Abrin is a toxin of public health concern due to its lethality, lack of antidote, and potential for use as a bioterrorism agent. Possible routes of exposure include ingestion, inhalation, and injection. Onset of symptoms is often delayed, even in severe cases. In fatal cases, death occurs from multi-organ failure. We describe the clinical course, laboratory, and pathologic findings in a case of fatal human poisoning associated with abrin injection. The seeds in this case were obtained the internet. The Centers for Disease Control and Prevention's Laboratory Response Network detected abrine in the urine confirming abrin exposure in this fatal poisoning.
相思豆毒素是一种具有公共卫生意义的毒素，因为它具有致命性、缺乏解毒剂，并且可能被用作生物恐怖主义制剂。可能的暴露途径包括摄入、吸入和注射。即使在严重的情况下，症状的发作也常常是延迟的。在致命的情况下，死亡是由于多器官衰竭引起的。我们描述了一例与相思豆毒素注射相关的致命性人类中毒的临床经过、实验室和病理发现。该病例中的种子是从互联网上获得的。疾病控制和预防中心的实验室反应网络在尿液中检测到相思豆毒素，证实了这种致命性中毒中相思豆毒素的暴露。
