Rare and Complex Epilepsies, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children's Hospital, IRCCS, 4, Piazza Sant'Onofrio, Rome 00165, Italy.
Neurosurgery Unit, Department of Neuroscience and Neurorehabilitation, Bambino Gesù Children's Hospital, IRCCS, 4, Piazza Sant'Onofrio, Rome 00165, Italy.
Neurosurg Clin N Am. 2020 Jul;31(3):335-344. doi: 10.1016/j.nec.2020.03.012.
Epilepsy is characterized by specific alterations in network organization. The main parameters at the basis of epileptogenic network formation are alterations of cortical thickness, development of pathologic hubs, modification of hub distribution, and white matter alterations. The effect is a reinforcement of brain connectivity in both the epileptogenic zone and the propagation zone. Moreover, the epileptogenic network is characterized by some specific neurophysiologic biomarkers that evidence the tendency of the network itself to shift from an interictal state to an ictal one. The recognition of these features is crucial in planning epilepsy surgery.
癫痫的特征是网络组织的特定改变。致痫网络形成的主要参数是皮质厚度的改变、病理性枢纽的发展、枢纽分布的改变和白质改变。其结果是增强了致痫区和传播区的脑连接。此外，致痫网络还具有一些特定的神经生理生物标志物，这些标志物表明网络本身有从间歇期状态转变为发作期状态的趋势。识别这些特征对于规划癫痫手术至关重要。
