Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, OH, USA.
AMIA Annu Symp Proc. 2022 Feb 21;2021:1019-1028. eCollection 2021.
Alterations in consciousness state are a defining characteristic of focal epileptic seizures. Consequently, understanding the complex changes in neurocognitive networks which underpin seizure-induced alterations in consciousness state is important for advancement in seizure classification. Comprehension of these changes are complicated by a lack of data standardization; however, the use of a common terminological system or ontology in a patient registry minimizes this issue. In this paper, we introduce an integrated knowledgebase called to improve the understanding of changes in consciousness states during focal seizures of pharmacoresistant epilepsy patients. This registry catalogues over 809 seizures from 70 patients at University Hospital's Epilepsy Center who were undergoing stereotactic electroencephalography (SEEG) monitoring as part of an evaluation for surgical intervention. Although Epilepsy-Connect focuses on consciousness states, it aims to enable users to leverage data from an informatics platform to analyze epilepsy data in a streamlined manner. Epilepsy-Connect is available at https://bmhinformatics.case.edu/Epilepsyconnect/login/.
意识状态的改变是局灶性癫痫发作的一个明确特征。因此，了解支持癫痫发作引起的意识状态改变的神经认知网络的复杂变化对于癫痫分类的进展很重要。由于缺乏数据标准化，对这些变化的理解变得复杂；然而，在患者登记处使用通用术语系统或本体可以最大限度地减少这个问题。在本文中，我们介绍了一个名为 的集成知识库，以提高对耐药性癫痫患者局灶性癫痫发作期间意识状态变化的理解。该登记册收录了来自大学医院癫痫中心的 70 名患者的 809 次癫痫发作，这些患者正在接受立体脑电图 (SEEG) 监测，作为手术干预评估的一部分。尽管 Epilepsy-Connect 专注于意识状态，但它旨在使用户能够利用信息学平台的数据以简化的方式分析癫痫数据。Epilepsy-Connect 可在 https://bmhinformatics.case.edu/Epilepsyconnect/login/ 获得。
