Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, 3801 Rue Université, Montreal, Quebec H3A 2B4, Canada.
Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, 3801 Rue Université, Montreal, Quebec H3A 2B4, Canada.
Neurosurg Clin N Am. 2020 Jul;31(3):395-405. doi: 10.1016/j.nec.2020.03.004. Epub 2020 Apr 23.
Continuing advancements in neuroimaging methodology allow for increasingly detailed in vivo characterization of structural and functional brain networks, leading to the recognition of epilepsy as a disorder of large-scale networks. In surgical candidates, analysis of functional networks has proved invaluable for the identification of eloquent brain areas, such as hemispherical language dominance. More recently, connectome-based biomarkers have demonstrated potential to further inform clinical decision making in drug-refractory epilepsy. This article summarizes current evidence on epilepsy as a network disorder, emphasizing potential benefits of network analysis techniques for preoperative assessments and resection planning.
神经影像学方法的不断进步使得对结构和功能脑网络进行越来越详细的体内特征描述成为可能，从而将癫痫识别为一种大规模网络障碍。在手术候选者中，功能网络分析已被证明对于识别语言优势半球等功能区具有重要意义。最近，基于连接组学的生物标志物已显示出在药物难治性癫痫的临床决策中提供信息的潜力。本文总结了目前关于癫痫作为一种网络障碍的证据，强调了网络分析技术在术前评估和切除规划中的潜在益处。
