Sum Samuth, Park Hee Myung, Oh Jae Young
Department of Veterinary Internal Medicine, Konkuk University College of Veterinary Medicine, Seoul, Korea.
J Vet Sci. 2020 May;21(3):e40. doi: 10.4142/jvs.2020.21.e40.
The purpose of this study was to investigate the high-level mupirocin resistance (HLMR) in Gram-positive bacteria isolated from companion animals. A total of 931 clinical specimens were collected from diseased pets. The detection of mupirocin-resistant bacteria and plasmid-mediated mupirocin resistance genes were evaluated by antimicrobial susceptibility tests, polymerase chain reactions, and sequencing analysis. Four-hundred and six (43.6%) bacteria were isolated and 17 (4.2%), including 14 staphylococci and 3 were high-level mupirocin-resistant (MICs, ≥ 1,024 ug/mL) harboring . Six staphylococci of HLMR strains had plasmid-mediated -IS flanking regions. The results show that HLMR bacteria could spread in veterinary medicine in the near future.
本研究的目的是调查从伴侣动物分离出的革兰氏阳性菌中的高耐莫匹罗星（HLMR）情况。总共从患病宠物身上采集了931份临床标本。通过抗菌药敏试验、聚合酶链反应和测序分析对耐莫匹罗星细菌和质粒介导的莫匹罗星耐药基因进行检测。分离出406株（43.6%）细菌，其中17株（4.2%）为高耐莫匹罗星（MICs≥1024μg/mL），包括14株葡萄球菌和3株 。6株HLMR菌株的葡萄球菌具有质粒介导的 -IS侧翼区域。结果表明，HLMR细菌在不久的将来可能会在兽医学中传播。
