Bhatt R K, Agarwal M
1Department of Obstetrics and Gynaecology, Army Hospital Research and Referral, New Delhi, India.
2Department of Lab Sciences and Molecular Medicine, Army Hospital Research and Referral, New Delhi, India.
J Obstet Gynaecol India. 2020 Jun;70(3):189-194. doi: 10.1007/s13224-020-01305-9. Epub 2020 Feb 8.
Recurrent pregnancy losses (RPLs) are seen in up to 15-20% of all clinically recognized pregnancies, 1-2% of women in general population. Repeated losses are seen in 5-10% of women. The prevalence of chromosomal rearrangements is 6.65% in couples with repeated pregnancy losses. Two to 4% of RPL are associated with parental balanced reciprocal and Robertsonian translocations.
The study was conducted at a tertiary care hospital in New Delhi, and in total, 204 couples with RPL enrolled in the study.
In total, 4490 couples presented to the obstetric clinic, of which 204 (4.5%) couples had repeated pregnancy losses. Cytogenetic analysis was done in 198 couples. Out of total 198 patients, 14 patients (7.1%) had cytogenetic alterations. Most common aberrations observed were structural rearrangements, of which reciprocal translocations were more common. In our study cohort, all the couples had maternal age of ≤ 35 years and all the alterations were seen either in mother or in both parents.
Our study highlights that cytogenetic alterations not only are common in first trimester miscarriages, but are an important event in miscarriages presenting at later period of gestation and in young mothers as well.
复发性流产（RPL）在所有临床确诊的妊娠中发生率高达15% - 20%，在普通人群中的女性发生率为1% - 2%。5% - 10%的女性会出现反复流产。在复发性流产的夫妇中，染色体重排的发生率为6.65%。2% - 4%的复发性流产与父母的平衡易位和罗伯逊易位有关。
该研究在新德里的一家三级护理医院进行，共有204对复发性流产夫妇参与了该研究。
总共有4490对夫妇前往产科门诊就诊，其中204对（4.5%）夫妇有复发性流产。对198对夫妇进行了细胞遗传学分析。在总共198名患者中，14名患者（7.1%）有细胞遗传学改变。观察到的最常见异常是结构重排，其中相互易位更为常见。在我们的研究队列中，所有夫妇的母亲年龄均≤35岁，所有改变均见于母亲或父母双方。
我们的研究强调，细胞遗传学改变不仅在孕早期流产中常见，而且在妊娠后期流产以及年轻母亲流产中也是一个重要事件。
