Dong Y, Li L L, Wang R X, Yu X W, Yun X, Liu R Z
Center for Reproductive Medicine, Center for Prenatal Diagnosis, First Hospital, Jilin University, Changchun, China.
Department of Cell Biology, Norman Bethune College of Medicine, Jilin University, Changchun, China.
Genet Mol Res. 2014 Jan 17;13(2):2849-56. doi: 10.4238/2014.January.17.4.
The subsequent reproductive outcomes in couples with a history of recurrent pregnancy loss (RPL) associated with chromosome abnormalities or polymorphisms are generally not reported in China. Many RPL carrier couples have decided not to have children. The present study recorded the subsequent delivery, miscarriage, and unpregnancy outcomes of 113 RPL carrier couples and 226 non-carrier couples, and compared differences in reproductive outcomes between couples with different types of chromosome abnormalities or polymorphisms and chromosome normal couples. Our results showed that couples with RPL associated with parental chromosome abnormalities or polymorphisms did not have significantly lower live birth rates than non-carrier couples in China. These results suggest the current guidance given to Chinese RPL couples.
在中国，通常不会报告有染色体异常或多态性相关复发性流产（RPL）病史的夫妇随后的生殖结局。许多RPL携带者夫妇决定不生育。本研究记录了113对RPL携带者夫妇和226对非携带者夫妇随后的分娩、流产和未孕结局，并比较了不同类型染色体异常或多态性夫妇与染色体正常夫妇之间生殖结局的差异。我们的结果表明，在中国，与父母染色体异常或多态性相关的RPL夫妇的活产率并不显著低于非携带者夫妇。这些结果为中国RPL夫妇提供了当前的指导建议。
