Giulia Patricelli, Carla Galeone, Cristian Rapicetta, Riccardo Valli, Maria Cecilia Mengoli, Cristiano Carbonelli, Massimiliano Paci, Filippo Lococo
Unit of Thoracic Surgery.
Unit of Pathology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
Sarcoidosis Vasc Diffuse Lung Dis. 2017;34(3):260-263. doi: 10.36141/svdld.v34i3.5942. Epub 2020 Mar 9.
Primary pulmonary extra-nodal MALT-lymphomas are very uncommon. Clinical-radiological pattern is variable and usually non-specific and a correct diagnosis usually requires the histopathological examination. Herein we report a case of a 59-year-old man presented with dyspnea at the slightest effort and dry cough. At imaging multiple pulmonary consolidations with interlobular septal thickenings and ground-glass opacities were disclosed, defining a crazy paving pattern. The surgical approach was necessary to reach the diagnosis of primary pulmonary low-grade marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT-lymphoma). Immunotherapy (Rituximab) and chemotherapy (Bendamustine) were started leading to a progressive improvement of the disease. .
原发性肺结外黏膜相关淋巴组织淋巴瘤（MALT淋巴瘤）非常罕见。临床放射学表现多样，通常不具有特异性，正确诊断通常需要组织病理学检查。在此，我们报告一例59岁男性病例，该患者稍有活动即出现呼吸困难和干咳。影像学检查发现多个肺实变影，伴有小叶间隔增厚和磨玻璃影，形成铺路石样表现。为明确诊断原发性肺低度边缘区黏膜相关淋巴组织B细胞淋巴瘤（MALT淋巴瘤），需要采取手术方法。开始进行免疫治疗（利妥昔单抗）和化疗（苯达莫司汀）后，病情逐渐改善。
