Üzmezoğlu Bilge, Şimşek Cebrail, Gülgösteren Sevtap, Gebeşoğlu Berna, Sarı Gülden, Çelik Deniz
Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Occupational Diseases Clinic, Ankara, Turkey.
Sarcoidosis Vasc Diffuse Lung Dis. 2017;34(4):365-372. doi: 10.36141/svdld.v34i4.6185. Epub 2017 Apr 28.
Sarcoidosis is a disease of unknown etiology. Despite the proposed connection between the development of sarcoidosis and exposure to environmental and toxic substances, no definitive associations could be established. Also, the role of silica and silicates in the etiology of this condition is currently unknown. Heat-treatment of silica results in the generation of tridymite and cristobalite forms and iron-steel industry represents one branch of industry in which silicone element is exposed to temperatures around 2000°C. Studies reporting on the incidence of sarcoidosis in the workers of iron-steel industry are scarce in number, and workers of this industrial branch are known to be exposed to silica in the form of cristobalite, nano-particulate silicone, metal oxides, and silicates. These substances, which have respiratory toxic properties and have been reported to be associated with autoimmune conditions, may also play a role in the pathogenesis of sarcoidosis. In our clinic, sarcoidosis was diagnosed in a total of 4 individuals, who works in the iron-steel industry. Through this report involving a series of patients with sarcoidosis, we also wanted to discuss the role of crystalline silica forms and silicates in the etiology of sarcoidosis, which is also considered to be an auto-immune condition. .
结节病是一种病因不明的疾病。尽管有人提出结节病的发生与接触环境和有毒物质之间存在联系，但尚未能确定明确的关联。此外，二氧化硅和硅酸盐在这种疾病病因中的作用目前尚不清楚。二氧化硅的热处理会产生鳞石英和方石英形态，钢铁行业是其中一个行业分支，在该行业中硅元素会暴露于约2000°C的温度下。关于钢铁行业工人结节病发病率的研究数量稀少，已知该行业分支的工人会接触到方石英、纳米颗粒硅、金属氧化物和硅酸盐形式的二氧化硅。这些具有呼吸道毒性且据报道与自身免疫性疾病有关的物质，也可能在结节病的发病机制中起作用。在我们的诊所，共诊断出4名在钢铁行业工作的个体患有结节病。通过这份涉及一系列结节病患者的报告，我们还想探讨结晶二氧化硅形态和硅酸盐在结节病病因中的作用，结节病也被认为是一种自身免疫性疾病。
