Lee Yan Ho, Park Eunice, Lee Jonathan, Lawson William
Department of General Surgery, Section of Otolaryngology, Yale School of Medicine, New Haven, Connecticut, USA.
Department of Otlaryngology, Head and Neck Surgery, North Shore/Long Island Jewish Medical Center, New Hyde Park, New York, USA.
Sarcoidosis Vasc Diffuse Lung Dis. 2018;35(1):69-73. doi: 10.36141/svdld.v35i1.6261. Epub 2018 Apr 28.
Subcutaneous sarcoidosis is a rare manifestation of a systemic disease. Sarcoidosis most often affects the pulmonary system but can also affect sinonasal tissues including the cutaneous and subcutaneous layers. It can be suspected in patients who may or may not have a prior diagnosis of sarcoidosis but who develop nodules or lesions over the nasal dorsum after trauma or rhinoplasty. The onset may also be spontaneous with diffuse enlargement of the nose. The diagnosis can be confirmed with tissue biopsy. Management is primarily medical with topical, intralesional, or systemic steroids. When medical management has failed, surgical options can be considered. We present a total of four patients with subcutaneous nasal sarcoidosis. Two patients had diffuse subcutaneous sarcoidosis that improved significantly with medical therapy. Two other patients with post-traumatic nodule formation were managed with intralesional steroids and surgery. .
皮下结节病是一种全身性疾病的罕见表现。结节病最常累及肺部系统，但也可累及包括皮肤和皮下层在内的鼻旁窦组织。对于可能有或没有结节病既往诊断，但在创伤或鼻整形术后鼻背部出现结节或病变的患者，应怀疑有该病。发病也可能是自发的，表现为鼻子弥漫性肿大。组织活检可确诊。治疗主要是药物治疗，使用局部、病灶内或全身性类固醇。当药物治疗失败时，可以考虑手术选择。我们总共介绍了4例皮下鼻结节病患者。2例患者患有弥漫性皮下结节病，药物治疗后有显著改善。另外2例创伤后结节形成的患者采用病灶内类固醇和手术治疗。
