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一例使用甲氨蝶呤成功治疗的类固醇难治性心脏结节病病例报告。

A case report of steroid resistant cardiac sarcoidosis successfully managed with methotrexate.

作者信息

Grabowska Olga, Martusewicz-Boros Magdalena M, Piotrowska-Kownacka Dorota, Wiatr Elżbieta

机构信息

Mazovian Center For Treatment of Lung Diseases and Tuberculosis, Otwock, Poland.

3 Lung Diseases Dept., National TB & Lung Diseases Research Institute, Warsaw, Poland.

出版信息

Sarcoidosis Vasc Diffuse Lung Dis. 2018;35(2):178-181. doi: 10.36141/svdld.v35i2.6554. Epub 2018 Apr 28.

DOI:10.36141/svdld.v35i2.6554
PMID:32476900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7170091/
Abstract

Up to one fourth of sarcoidosis patients may have cardiac involvement, what is potentially a life-threatening condition and requires aggressive treatment. Corticosteroids are generally effective in cardiac sarcoidosis, however may have significant short and long term adverse effects. We present a case of a 42-year-old male, who was diagnosed with pulmonary and cardiac sarcoidosis. He was treated initially with corticosteroids and satisfactory improvement was achieved in the lungs but not in the heart. Methotrexate was added as a second line therapy, being beneficial for the heart as well as steroid sparing agent. Cardiac improvement was documented during serial CMR imaging. .

摘要

高达四分之一的结节病患者可能有心脏受累,这可能是一种危及生命的情况,需要积极治疗。皮质类固醇通常对心脏结节病有效,但可能有显著的短期和长期不良反应。我们报告一例42岁男性,被诊断为肺和心脏结节病。他最初接受皮质类固醇治疗,肺部取得了满意的改善,但心脏没有改善。添加甲氨蝶呤作为二线治疗,对心脏有益且可作为类固醇节省剂。在连续的心脏磁共振成像中记录到心脏有所改善。

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Sarcoidosis Vasc Diffuse Lung Dis. 2018;35(2):178-181. doi: 10.36141/svdld.v35i2.6554. Epub 2018 Apr 28.
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本文引用的文献

1
Prevalence of cardiac sarcoidosis in white population: a case-control study: Proposal for a novel risk index based on commonly available tests.白种人群中心肌结节病的患病率:一项病例对照研究:基于常用检查提出一种新型风险指数的建议。
Medicine (Baltimore). 2016 Aug;95(32):e4518. doi: 10.1097/MD.0000000000004518.
2
The three tiers of screening for sarcoidosis organ involvement.结节病器官受累的三级筛查
Respir Med. 2016 Apr;113:42-9. doi: 10.1016/j.rmed.2016.02.011. Epub 2016 Feb 23.
3
Effect of Corticosteroid Therapy on Long-Term Clinical Outcome and Left Ventricular Function in Patients With Cardiac Sarcoidosis.皮质类固醇疗法对心脏结节病患者长期临床结局及左心室功能的影响
Circ J. 2015;79(7):1593-600. doi: 10.1253/circj.CJ-14-1275. Epub 2015 Apr 16.
4
HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis.心脏结节病相关心律失常诊断与管理的HRS专家共识声明
Heart Rhythm. 2014 Jul;11(7):1305-23. doi: 10.1016/j.hrthm.2014.03.043. Epub 2014 May 9.
5
The WASOG Sarcoidosis Organ Assessment Instrument: An update of a previous clinical tool.WASOG结节病器官评估工具:既往临床工具的更新
Sarcoidosis Vasc Diffuse Lung Dis. 2014 Apr 18;31(1):19-27.
6
Treatment with methotrexate and low-dose corticosteroids in sarcoidosis patients with cardiac lesions.用甲氨蝶呤和低剂量皮质类固醇治疗患有心脏病变的结节病患者。
Intern Med. 2014;53(5):427-33. doi: 10.2169/internalmedicine.53.0794.
7
Cardiac sarcoid: a clinician's review on how to approach the patient with cardiac sarcoid.心脏结节病:临床医生如何处理心脏结节病患者的综述。
Clin Cardiol. 2012;35(7):410-5. doi: 10.1002/clc.21982. Epub 2012 Apr 12.
8
Cardiac sarcoidosis: a retrospective study of 41 cases.心脏结节病:41例回顾性研究
Medicine (Baltimore). 2004 Nov;83(6):315-334. doi: 10.1097/01.md.0000145367.17934.75.
9
Clinical characteristics of patients in a case control study of sarcoidosis.结节病病例对照研究中患者的临床特征
Am J Respir Crit Care Med. 2001 Nov 15;164(10 Pt 1):1885-9. doi: 10.1164/ajrccm.164.10.2104046.
10
Prognostic determinants of long-term survival in Japanese patients with cardiac sarcoidosis treated with prednisone.接受泼尼松治疗的日本心脏结节病患者长期生存的预后决定因素。
Am J Cardiol. 2001 Nov 1;88(9):1006-10. doi: 10.1016/s0002-9149(01)01978-6.