神经结节病患者的日常认知功能衰退
Everyday cognitive failure in patients suffering from neurosarcoidosis.
作者信息
Voortman Mareye, De Vries Jolanda, Hendriks Celine M R, Elfferich Marjon D P, Wijnen Petal A H M, Drent Marjolein
机构信息
ILD Center of Excellence, Department of Pulmonology, St. Antonius Hospital, Nieuwegein, The Netherlands.
Department of Pulmonology, Division of Heart & Lungs, University Medical Centre Utrecht, The Netherlands.
出版信息
Sarcoidosis Vasc Diffuse Lung Dis. 2019;36(1):2-10. doi: 10.36141/svdld.v36i1.7412. Epub 2019 May 1.
BACKGROUND
Cognitive failure is associated with memory and concentration problems. Previously, a prevalence of one third was found in a general sarcoidosis population. The aim of this study was to assess if neurosarcoidosis patients are at higher risk for developing everyday cognitive failure using the Cognitive Failure Questionnaire (CFQ) and to determine what factors were associated with cognitive failure.
METHODS
A cross-sectional web-based survey was conducted from April to May 2017 in a national sample of neurosarcoidosis patients. The survey asked about complaints and included 3 questionnaires (Fatigue Assessment Scale [FAS], Small Fiber Neuropathy Screening List [SFNSL] and CFQ. Data were compared to a general sarcoidosis population.
RESULTS
Of the 152 patients who completed the survey, 131 had neurosarcoidosis. The mean CFQ score was significantly higher in the neurosarcoidosis (45.6±20.7) compared to the general sarcoidosis population (36.2±15.9; p< 0.0001). High CFQ scores (≥43) were found in 55.7% and 33.9%, respectively (p<0.0001). The FAS score (OR 21.4) and SFNSL score (OR 4.3) were the strongest positive predictors of a high CFQ score.
CONCLUSION
Cognitive failure is a significant problem in neurosarcoidosis. More than half of the patients reported cognitive deficits, compared to one third of a general sarcoidosis population. Fatigue and small fiber neuropathy play a role in cognitive failure.
背景
认知功能障碍与记忆和注意力问题相关。此前，在结节病普通人群中发现三分之一的患病率。本研究的目的是使用认知功能障碍问卷（CFQ）评估神经结节病患者发生日常认知功能障碍的风险是否更高，并确定哪些因素与认知功能障碍相关。
方法
2017年4月至5月，对全国神经结节病患者样本进行了基于网络的横断面调查。该调查询问了相关症状，并包括3份问卷（疲劳评估量表[FAS]、小纤维神经病变筛查清单[SFNSL]和CFQ）。将数据与结节病普通人群进行比较。
结果
在完成调查的152例患者中，131例患有神经结节病。神经结节病患者的CFQ平均得分（45.6±20.7）显著高于结节病普通人群（36.2±15.9；p<0.0001）。CFQ高分（≥43）分别在55.7%和33.9%的患者中出现（p<0.0001）。FAS得分（OR 21.4）和SFNSL得分（OR 4.3）是CFQ高分最强的阳性预测因素。
结论
认知功能障碍在神经结节病中是一个重要问题。超过一半的患者报告有认知缺陷，而结节病普通人群中这一比例为三分之一。疲劳和小纤维神经病变在认知功能障碍中起作用。
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