Simitchiev S, Bodurov I
Vutr Boles. 1988;27(6):14-20.
129 patients with peptic ulcer in the acute stage of the disease were studied clinically, roentgenologically, endoscopically and morphologically. The patients were classified into two groups--with or without dyspeptic syndrome. The gastric acidity was examined by the fractionary titration method with pentagastrin as stimulant, Reflux-esophagitis was found in patients with hyperacidity as well as in patients with normal and hypoacidity. The destructive changes in the esophageal epithelium were more frequent in the patients with duodenal ulcer--12.9% than in the patients with gastric ulcer. The reflux-esophagitis was found three times less in the patients with peptic ulcer without dyspeptic syndrome than in the patients with peptic ulcer with dyspeptic syndrome, without reliable differences in the secretory indices between the two groups. The conclusion is made that the gastric acidity without functional disorders in the gastroesophageal segment is not a decisive factor in the development of the dyspeptic syndrome in peptic ulcer.
对129例处于疾病急性期的消化性溃疡患者进行了临床、X线、内镜及形态学研究。患者被分为两组——有或无消化不良综合征。采用以五肽胃泌素为刺激剂的分段滴定法检测胃酸度。胃酸过多以及胃酸正常和过少的患者均发现有反流性食管炎。十二指肠溃疡患者食管上皮的破坏性改变比胃溃疡患者更常见——分别为12.9%和胃溃疡患者。无消化不良综合征的消化性溃疡患者中反流性食管炎的发生率比有消化不良综合征的消化性溃疡患者少两倍，两组之间的分泌指标无可靠差异。得出的结论是，胃食管段无功能障碍时的胃酸度不是消化性溃疡患者发生消化不良综合征的决定性因素。
