Central Laboratory of Hematology and Oncology, First Affiliated Hospital, Harbin Medical University, Harbin, China.
College of Life Science, Northeast Agricultural University, Harbin, China.
Front Immunol. 2020 May 12;11:792. doi: 10.3389/fimmu.2020.00792. eCollection 2020.
Conditions in which abnormal or excessive immune responses exist, such as autoimmune diseases (ADs), graft-versus-host disease, transplant rejection, and hypersensitivity reactions, are serious hazards to human health and well-being. The traditional immunosuppressive drugs used to treat these conditions can lead to decreased immune function, a higher risk of infection, and increased tumor susceptibility. As an alternative therapeutic approach, cell therapy, in which generally intact and living cells are injected, grafted, or implanted into a patient, has the potential to overcome the limitations of traditional drug treatment and to alleviate the symptoms of many refractory diseases. Cell therapy could be a powerful approach to induce immune tolerance and restore immune homeostasis with a deeper understanding of immune tolerance mechanisms and the development of new techniques. The purpose of this review is to describe the current panoramic scope of cell therapy for immune-mediated disorders, discuss the advantages and disadvantages of different types of cell therapy, and explore novel directions and future prospects for these tolerogenic therapies.
在存在异常或过度免疫反应的情况下，如自身免疫性疾病 (AD)、移植物抗宿主病、移植排斥和超敏反应，这些都是对人类健康和福祉的严重危害。用于治疗这些疾病的传统免疫抑制剂会导致免疫功能下降、感染风险增加和肿瘤易感性增加。作为一种替代治疗方法，细胞疗法通常将完整和存活的细胞注入、移植或植入患者体内，具有克服传统药物治疗局限性和缓解许多难治性疾病症状的潜力。随着对免疫耐受机制的深入了解和新技术的发展，细胞疗法可能成为诱导免疫耐受和恢复免疫平衡的有力方法。本文旨在描述细胞疗法治疗免疫介导性疾病的当前全景范围，讨论不同类型细胞疗法的优缺点，并探索这些耐受疗法的新方向和未来前景。
