异维A酸治疗后妊娠的洗脱期。
Washout Period for Pregnancy Post Isotretinoin Therapy.
作者信息
Jajoria Hina, Mysore Venkataram
机构信息
Dermatology, Venereology and Leprosy, The Venkat Center for Skin and Plastic Surgery - Post Graduate Training Center (Affiliated to RGUHS), Subbanna Garden, Bengaluru, Karnataka, India.
出版信息
Indian Dermatol Online J. 2020 Mar 9;11(2):239-242. doi: 10.4103/idoj.IDOJ_101_19. eCollection 2020 Mar-Apr.
INTRODUCTION AND BACKGROUND
Isotretinoin is an oral medication used for the treatment of severe acne unresponsive to other medications. This drug is teratogenic and should be prescribed with appropriate caution in selected group of patients. The washout period for pregnancy post isotrenoin therapy has always been a topic of controversy. Several guidelines have recommended a wash out period of one month if pregnancy is planned in a patient being administered with the drug.
OBJECTIVE
This article discusses the available evidence for different recommended wash out periods and addresses important clinical questions that arise.
METHODS
Pubmed research was carried out to collect relevant data using the keywords isotretinoin, pregnancy, contraception, pharmacokinetics and guidelines.
CONCLUSION
Our research based on the published data concludes that a wash out period of 35 days post isotretinoin therapy is adequate in routine clinical practice.
引言与背景
异维A酸是一种口服药物，用于治疗对其他药物无反应的重度痤疮。该药物具有致畸性，在特定患者群体中应谨慎处方。异维A酸治疗后怀孕的洗脱期一直是一个有争议的话题。一些指南建议，如果计划怀孕的患者正在服用该药物，洗脱期为一个月。
目的
本文讨论了不同推荐洗脱期的现有证据，并解决了出现的重要临床问题。
方法
使用关键词异维A酸、怀孕、避孕、药代动力学和指南进行PubMed研究，以收集相关数据。
结论
我们基于已发表数据的研究得出结论，在常规临床实践中，异维A酸治疗后35天的洗脱期就足够了。
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