Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Clinical Services, St Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
BJOG. 2020 Dec;127(13):1704-1711. doi: 10.1111/1471-0528.16340. Epub 2020 Jul 5.
To assess the association between levels of vitamin D and urinary incontinence (UI) in pregnancy.
A cross-sectional study. Secondary analysis of a randomised controlled trial.
Two university hospitals in Norway.
A total of 851 healthy, pregnant women >18 years in gestational weeks 18-22 with a singleton live fetus.
Data on UI were collected from a questionnaire at inclusion and serum analysis of 25-hydroxy vitamin D (25(OH)D) was performed. Univariable and multivariable logistic regression analyses were applied to study associations between exposure and outcomes.
Prevalence of self-reported UI, stress (SUI) and urge (UUI) or mixed UI.
In total, 230/851 (27%) of the participants were vitamin D insufficient (25(OH)D <50 nmol/l) and 42% reported to have any UI. Women with 25(OH)D <50 nmol/l were more likely to report any UI (P = 0.03) and SUI (P < 0.01) compared with women with 25(OH)D ≥50 nmol/l. In a univariable logistic regression analysis, serum levels of 25(OH)D <50 nmol/l was associated with increased risk of any UI (odds ratio [OR] 1.5 with 95% CI 1.0-2.1), SUI only (OR 1.7, 95% CI 1.2-2.4), but not mixed UI or UUI only (OR 0.8, 95% CI 0.5-1.5). In a multivariable logistic regression model, serum levels of 25(OH)D <50 nmol/l were associated with a higher risk of experiencing SUI only (OR 1.5, 95% CI 1.1-2.2).
Serum 25(OH)D <50 nmol/l was associated with increased risk of any UI, and SUI in particular.
Low levels of vitamin D are associated with increased risk of urinary incontinence in pregnancy.
评估妊娠期间维生素 D 水平与尿失禁（UI）之间的关联。
横断面研究。一项随机对照试验的二次分析。
挪威的两所大学医院。
共有 851 名年龄大于 18 岁、妊娠 18-22 周、怀有单胎活胎的健康孕妇。
在纳入时通过问卷收集 UI 数据，并进行血清 25-羟维生素 D（25(OH)D）分析。应用单变量和多变量逻辑回归分析来研究暴露与结局之间的关系。
自我报告的 UI、压力性尿失禁（SUI）和急迫性尿失禁（UUI）或混合性 UI 的患病率。
共有 230/851（27%）名参与者存在维生素 D 不足（25(OH)D<50nmol/l），42%的参与者报告有任何 UI。与 25(OH)D≥50nmol/l 的女性相比，25(OH)D<50nmol/l 的女性更有可能报告任何 UI（P=0.03）和 SUI（P<0.01）。在单变量逻辑回归分析中，血清 25(OH)D<50nmol/l 与 UI 风险增加相关（比值比 [OR] 1.5，95%置信区间 1.0-2.1），SUI 单独发生（OR 1.7，95%置信区间 1.2-2.4），但与混合性 UI 或 UUI 单独发生（OR 0.8，95%置信区间 0.5-1.5）无关。在多变量逻辑回归模型中，血清 25(OH)D<50nmol/l 与发生 SUI 的风险增加相关（OR 1.5，95%置信区间 1.1-2.2）。
血清 25(OH)D<50nmol/l 与妊娠期间任何 UI 的风险增加相关，尤其是 SUI。
低水平的维生素 D 与妊娠期间尿失禁的风险增加有关。
