Centre of Inflammation and Metabolism/Centre for Physical Activity Research (CIM/CFAS), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Centre of Inflammation and Metabolism/Centre for Physical Activity Research (CIM/CFAS), Rigshospitalet, University of Copenhagen, Copenhagen, Denmark; The Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen University Hospital, 2200 Copenhagen, Denmark.
Curr Opin Pharmacol. 2020 Jun;52:18-24. doi: 10.1016/j.coph.2020.04.004. Epub 2020 May 29.
Browning of white adipose tissue is a cold-induced phenomenon in rodents, constituted by the differentiation of a subset of thermogenic adipocytes among existing white adipocytes. Emerging evidence in the literature points at additional factors and environmental conditions stimulating browning in rodents, including physical exercise training. Exercise engages sympathetic activation which during cold activation promotes proliferation and differentiation of brown preadipocytes. Exercise also stimulates the release of multiple growth factors and cytokines. Importantly, there are clear discrepancies between human and rodents with regard to thermogenic capacity and browning potential. Here we provide a translational perspective on exercise-induced browning and review recent findings on the role of myokines and hepatokines in this process.
白色脂肪组织的褐色化是啮齿动物在寒冷环境下产生的一种现象，它由存在于白色脂肪细胞中的一部分产热脂肪细胞分化而来。文献中的新证据表明，还有其他因素和环境条件可以刺激啮齿动物的褐色化，包括体育锻炼。运动可激活交感神经，在寒冷环境下促进棕色前脂肪细胞的增殖和分化。运动还可刺激多种生长因子和细胞因子的释放。重要的是，人类和啮齿动物在产热能力和褐色化潜力方面存在明显差异。在这里，我们从转化医学的角度探讨运动诱导的褐色化，并综述了肌肉因子和肝脏因子在这一过程中的作用的最新发现。
