Department of Neurology and Neurosurgery, Institute of Clinical Medicine, University of Tartu, L. Puusepa 8, 50406 Tartu, Estonia; Neurology Clinic, Tartu University Hospital, L. Puusepa 8, 50406 Tartu, Estonia.
Department of Neurology and Neurosurgery, Institute of Clinical Medicine, University of Tartu, L. Puusepa 8, 50406 Tartu, Estonia; Department of Neurology, Internal Medicine Clinic, North Estonia Medical Centre Foundation, J. Sütiste 19, 13419 Tallinn, Estonia.
Neurotoxicology. 2020 Jan;76:138-143. doi: 10.1016/j.neuro.2019.10.007. Epub 2019 Oct 31.
Manganese-methcathinone encephalopathy (MME) is a rare parkinsonian syndrome described in drug addicts who have self-injected a home-made mixture containing methcathinone and manganese. We assessed 14 patients with MME and compared their results with 14 matched control subjects. The patients had a parkinsonian syndrome with symmetrical bradykinesia, dystonias, and postural, gait and speech impairment, with moderate restrictions in activities of daily living. Their cognitive status was assessed with the Russian version of the Wechsler Adult Intelligence Scale (WAIS) and with tests of attention (Trail Making Test, Bourdon-Wiersma Dot Cancellation Test), memory (Auditory Verbal Learning Test, Rey-Osterrieth Complex Figure), motor skills (Grooved Pegboard), visuospatial skills (Money Road Map Test, Benton Judgment of Line Orientation), and executive abilities (Verbal Fluency, 5-Point Test, Wisconsin Card Sorting Test). Only a few significant differences emerged. After controlling for multiple comparisons, the results in the WAIS Object Assembly subtest, the Grooved Pegboard test (dominant and nondominant hand) and the Verbal Fluency test remained significant.
锰-甲卡西酮性脑病（MME）是一种罕见的帕金森综合征，发生于自行注射含有甲卡西酮和锰的自制混合物的药物滥用者中。我们评估了 14 例 MME 患者，并将其结果与 14 例匹配的对照组进行比较。患者表现为帕金森综合征，伴有对称的运动徐缓、肌张力障碍和姿势、步态及言语障碍，日常生活活动能力中度受限。使用韦氏成人智力量表（WAIS）的俄语版和注意力测试（连线测试、布登沃尔斯曼点消去测试）、记忆测试（听觉词语学习测试、雷欧斯特利夫复杂图形测试）、运动技能测试（轨道钉板测试）、视空间技能测试（金钱道路地图测试、本顿线段判断测试）和执行能力测试（词语流畅性测试、5 点测试、威斯康星卡片分类测试）评估患者的认知状态。只有少数差异具有统计学意义。在控制了多次比较后，WAIS 物体组装子测试、轨道钉板测试（优势手和非优势手）和词语流畅性测试的结果仍然具有统计学意义。
