Department of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, Rhode Island Hospital, Providence, RI.
Department of Diagnostic Imaging, The Warren Alpert Medical School of Brown University, Providence, RI.
R I Med J (2013). 2020 Jun 1;103(5):26-29.
Chronic liver disease remains a substantial worldwide problem. Accurate estimation of liver fibrosis is crucial for determining the stage of the disease, assessing the patient's prognosis and predicting treatment response. Staging hepatic fibrosis has traditionally been done with liver biopsy but clinical practice has been changing, partly because liver biopsy has several disadvantages: it is invasive; it is associated with rare but serious complications; and it is prone to sampling error representing a tiny portion of the total liver volume. An increasing number of non-invasive liver fibrosis assessment have been developed. These include elastographic methods involving ultrasound (US) and magnetic resonance (MR) imaging. In this review article we discuss the different ultrasound-based elastography techniques, their clinical applications and various confounding factors in the assessment of hepatic fibrosis that may affect the accuracy of the measurements.
慢性肝脏疾病仍然是一个全球性的重大问题。准确评估肝纤维化对于确定疾病阶段、评估患者预后和预测治疗反应至关重要。肝纤维化的分期传统上是通过肝活检来完成，但临床实践一直在发生变化，部分原因是肝活检有几个缺点：它是侵入性的；它与罕见但严重的并发症有关；并且容易发生代表肝脏总容积一小部分的取样误差。越来越多的非侵入性肝纤维化评估方法已经得到开发。这些方法包括涉及超声（US）和磁共振（MR）成像的弹性成像方法。在这篇综述文章中，我们讨论了不同的基于超声的弹性成像技术、它们的临床应用以及在评估肝纤维化时可能影响测量准确性的各种混杂因素。
