Gil Sara, Mano João F
3B's Research Group - Biomaterials, Biodegradables and Biomimetics, ICVS/3B's - PT Government Associate Laboratory, AvePark, Zona Industrial da Gandra, S. Cláudio do Barco, 4806-909 Taipas, Guimarães, Portugal.
Biomater Sci. 2014 Jun 7;2(6):812-818. doi: 10.1039/c4bm00041b. Epub 2014 Mar 28.
Magnetic nanoparticles (MNPs) have been increasingly used in tissue engineering and regenerative medicine. These particles have been mainly employed as elements directly incorporated into cells or interacting with cell membranes; however, MNPs are now being combined with biomaterials to create other functionalities of the structural framework used to support cells, namely for controlling cellular responses and for enhancing drug delivery and release. This mini-review summarizes and highlights the latest developments and applications of polymeric/ceramic biomimetic scaffolds and hydrogels that contain MNPs for such purposes, also addressing future perspectives for the use of these magnetic composite biomaterials in biomedicine.
磁性纳米粒子(MNPs)在组织工程和再生医学中的应用日益广泛。这些粒子主要用作直接掺入细胞或与细胞膜相互作用的元素;然而,现在MNPs正与生物材料结合,以赋予用于支持细胞的结构框架其他功能,即用于控制细胞反应以及增强药物递送和释放。本综述总结并重点介绍了用于此类目的的含MNPs的聚合物/陶瓷仿生支架和水凝胶的最新进展及应用,还探讨了这些磁性复合生物材料在生物医学中的应用前景。