Baud C A, Very J M, Courvoisier B
Institut de Morphologie, Centre Médical Universitaire, Genève, Switzerland.
Bone. 1988;9(6):361-5. doi: 10.1016/8756-3282(88)90117-2.
Crystallographic characteristics of bone mineral were examined in a group of 60 osteoporotic patients before and after 3 to 6 years of fluoride therapy. The age of the mineral was evaluated by means of X-ray absorption, as degree of mineralization of bone tissue (MDBT). Crystallinity was evaluated by measuring both X-ray diffraction line broadening, beta (31.0) and beta (00.2), and the crystallinity index (CI) by infrared spectrometry. The a and c unit-cell parameters were determined by powder X-ray diffraction. Bone fluoride content was measured by specific electrode. Patients were divided in two groups according to MDBT before treatment: one group with MDBT values less than or equal to mean value; another group with MDBT values greater than mean value. In the first group, trabecular bone volume (TBV) did not change significantly during therapy. In the second group, an increase of TBV was observed. Osteoporoses can then be distinguished, on MDBT criterion, between osteoporosis with hypermaturated mineral and osteoporosis with hypomaturated mineral. The MDBT before treatment permits one to predict the effect of fluoride therapy on TBV. In the two groups there was a significant increase in bone fluoride content between the onset and the end of treatment. Bone fluoride content increased linearly during therapy without any plateau effect. Crystallographic modifications induced by fluoride explain the mechanical and chemical improvement of bone.
对一组60名骨质疏松患者在接受3至6年氟化物治疗前后的骨矿物质晶体学特征进行了检查。通过X射线吸收，以骨组织矿化程度（MDBT）来评估矿物质的年龄。通过测量X射线衍射线宽β(31.0)和β(00.2)以及用红外光谱法测量结晶度指数（CI）来评估结晶度。通过粉末X射线衍射确定a和c晶胞参数。用特定电极测量骨氟含量。根据治疗前的MDBT将患者分为两组：一组MDBT值小于或等于平均值；另一组MDBT值大于平均值。在第一组中，治疗期间小梁骨体积（TBV）没有明显变化。在第二组中，观察到TBV增加。根据MDBT标准，骨质疏松症可分为矿物质过度成熟的骨质疏松症和矿物质成熟不足的骨质疏松症。治疗前的MDBT可以预测氟化物治疗对TBV的效果。两组治疗开始和结束时骨氟含量均显著增加。治疗期间骨氟含量呈线性增加，没有任何平台效应。氟化物引起的晶体学改变解释了骨的力学和化学改善。
