HIV 感染者的睡眠与免疫功能。
Sleep and immune function among people living with human immunodeficiency virus (HIV).
机构信息
School of Nursing, Emory University, Atlanta, GA, USA.
School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
出版信息
AIDS Care. 2021 Sep;33(9):1196-1200. doi: 10.1080/09540121.2020.1770180. Epub 2020 Jun 1.
Abstract
People living with HIV are at increased risk for sleep disturbances. Up to 75% of the HIV-infected individuals in the United States experience sleep disturbances of some kind. Previous studies have suggested an association between patient-reported sleep disturbances and impaired immune function. This study evaluates data obtained via sleep actigraphy to evaluate the relationship between objectively measured sleep, HIV viral load, and immune function. While this study found no relationship between objective sleep and CD4+ T- lymphocyte count, higher sleep efficiency was weakly correlated with lower HIV viral loads, (93)= -.165, = .043. More research is warranted to clarify the nature of these relationships.
摘要
HIV 感染者睡眠紊乱的风险增加。高达 75%的美国 HIV 感染者存在某种程度的睡眠紊乱。既往研究提示，患者自述的睡眠紊乱与免疫功能受损有关。本研究通过睡眠描记术评估客观睡眠与 HIV 病毒载量和免疫功能之间的关系。本研究发现客观睡眠与 CD4+T 淋巴细胞计数之间无相关性，但较高的睡眠效率与较低的 HIV 病毒载量呈弱相关(r=−.165, P=.043)。需要进一步研究阐明这些关系的本质。
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