Department of Pediatric Surgery, Qilu Hospital of Shandong University, Jinan, China.
Institute of Traumatic Orthopedics, The 80th Army Hospital of the Chinese People's Liberation Army, Weifang, Shandong Province, China.
Aging (Albany NY). 2020 Jun 1;12(11):10633-10641. doi: 10.18632/aging.103283.
The study evaluates the serum levels of Trimethylamine N-Oxide (TMAO), a gut microbial metabolite, in 286 postmenopausal women with hip fracture. From January 1, 2018 to December 31, 2018, eligible patients were included. Same women without fracture mated age were enrolled. TMAO serum levels were tested by ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The serum levels of TMAO were significantly higher in patients with hip fracture than in those controls (P<0.001). The serum levels of TMAO were also higher in patients with hip fracture only than in those who also had upper limb fracture (P=0.001). High level of TMAO was proved a predictor of both hip fracture and had upper limb fracture combined hip fracture, after the adjustment of other existing risk factors [e.g., for each 1 uM increase of TMAO, odd ratio 1.16 (95% CI, 1.07-1.25), P < 0.001; and 1.12 (95% CI, 1.03-1.26), P=0.008, respectively]. In summary, increased TMAO serum levels associated with high risk of hip fracture, suggesting that increase TMAO may contribute to osteoporosis and fracture in postmenopausal women.
该研究评估了 286 名绝经后髋部骨折女性的血清三甲基胺 N-氧化物（TMAO）水平，TMAO 是一种肠道微生物代谢产物。研究纳入了 2018 年 1 月 1 日至 12 月 31 日的符合条件的患者。同时，还招募了年龄匹配、无骨折的女性作为对照。采用超高效液相色谱-串联质谱法（UHPLC-MS/MS）检测 TMAO 血清水平。与对照组相比，髋部骨折患者的 TMAO 血清水平显著升高（P<0.001）。与单纯髋部骨折患者相比，髋部骨折合并上肢骨折患者的 TMAO 血清水平更高（P=0.001）。校正其他现有危险因素后，高水平 TMAO 被证明是髋部骨折和上肢骨折合并髋部骨折的预测因素[例如，TMAO 每增加 1 uM，比值比分别为 1.16（95%CI，1.07-1.25），P<0.001；和 1.12（95%CI，1.03-1.26），P=0.008]。总之，TMAO 血清水平升高与髋部骨折风险增加相关，提示 TMAO 增加可能导致绝经后妇女骨质疏松和骨折。
