Lim Benjamin Syek Hur, Parolia Abhishek, Chia Margaret Soo Yee, Jayaraman Jayakumar, Nagendrababu Venkateshbabu
School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.
Division of Clinical Dentistry, School of Dentistry, International Medical University, Kuala Lumpur, Malaysia.
Restor Dent Endod. 2020 Mar 11;45(2):e23. doi: 10.5395/rde.2020.45.e23. eCollection 2020 May.
This study aimed to summarize the outcome of in vitro studies comparing the antibacterial effectiveness of QMix with other irrigants against .
The research question was developed by using population, intervention, comparison, outcome, and study design framework. The literature search was performed using 3 electronic databases: PubMed, Scopus, and EBSCOhost until October 2019. The additional hand search was performed from the reference list of the eligible studies. The risk of bias of the studies was independently appraised using the revised Cochrane Risk of Bias tool (RoB 2.0).
Fourteen studies were included in this systematic review. The overall risk of bias for the selected studies was moderate. QMix was found to have a higher antimicrobial activity compared to 2% sodium hypochlorite (NaOCl), 17% ethylenediaminetetraacetic acid (EDTA), 2% chlorhexidine (CHX), mixture of tetracycline isonomer, an acid and a detergent (MTAD), 0.2% Cetrimide, SilverSol/H2O2, HYBENX, and grape seed extract (GSE). QMix had higher antibacterial efficacy compared to NaOCl, only when used for a longer time (10 minutes) and with higher volume (above 3 mL).
QMix has higher antibacterial activity than 17% EDTA, 2% CHX, MTAD, 0.2% Cetrimide, SilverSol/H2O2, HYBENX, GSE and NaOCl with lower concentration. To improve the effectiveness, QMix is to use for a longer time and at a higher volume.
PROSPERO International prospective register of systematic reviews Identifier: CRD42018096763.
本研究旨在总结体外研究中比较QMix与其他冲洗剂抗菌效果的结果。
使用人群、干预措施、对照、结局和研究设计框架来提出研究问题。利用3个电子数据库进行文献检索：PubMed、Scopus和EBSCOhost，检索截至2019年10月。还从符合条件的研究的参考文献列表中进行了额外的手工检索。使用修订后的Cochrane偏倚风险工具（RoB 2.0）对研究的偏倚风险进行独立评估。
本系统评价纳入了14项研究。所选研究的总体偏倚风险为中等。发现QMix与2%次氯酸钠（NaOCl）、17%乙二胺四乙酸（EDTA）、2%氯己定（CHX）、四环素异构体、一种酸和一种洗涤剂的混合物（MTAD）、0.2%西曲溴铵、SilverSol/H2O2、HYBENX和葡萄籽提取物（GSE）相比，具有更高的抗菌活性。仅在使用较长时间（10分钟）和较大体积（3 mL以上）时，QMix与NaOCl相比具有更高的抗菌效果。
QMix比17% EDTA、2% CHX、MTAD、0.2%西曲溴铵、SilverSol/H2O2、HYBENX、GSE和低浓度的NaOCl具有更高的抗菌活性。为提高有效性，QMix应使用更长时间和更大体积。
PROSPERO国际前瞻性系统评价注册库标识符：CRD42018096763。
