Kumar Pravin, Soundharrajan P, Prakash Ram, Kombade Sarika Prabhakar, Yadav Pankaj, Chugh Ankita, Patnana Arun Kumar
Department of Dentistry, All India Institute of Medical Sciences, Jodhpur, India.
Department of Physics, Indian Institute of Technology, Jodhpur, India.
Biomater Investig Dent. 2023 Apr 21;10(1):2193214. doi: 10.1080/26415275.2023.2193214. eCollection 2023.
Cold Atmospheric Pressure (CAP) plasma has shown successful antibacterial efficacy in different medical applications which have prompted researchers to explore its possible use in endodontics. The aim of the present study was to comparatively evaluate the disinfection effectiveness of CAP Plasma jet with 5.25% sodium hypochlorite (NaOCl) and Qmix in infected root canals at different time intervals (2, 5, and 10 min). 210 single-rooted mandibular premolars were chemomechanically prepared and infected with . The test samples were exposed to CAP Plasma jet, 5.25% NaOCl, and Qmix for 2, 5, and 10 min. The residual bacteria from the root canals if any were collected and evaluated for colony-forming units (CFUs) growth. ANOVA and Tukey's tests were used to evaluate the significant difference between treatment groups. 5.25% NaOCl showed significantly more antibacterial effectiveness (<0.001) when compared with all other test groups except Qmix at 2 and 10 min of exposure time. A minimum contact time of 5 min with 5.25% NaOCl is recommended to get zero bacterial growth in infected root canals. QMix requires a minimum contact time of 10 min to achieve optimal CFUs reduction and CAP plasma jet requires a minimum contact time of 5 min to achieve substantial CFUs reduction.
冷大气压（CAP）等离子体在不同的医学应用中已显示出成功的抗菌效果，这促使研究人员探索其在牙髓病学中的可能用途。本研究的目的是比较评估CAP等离子体射流与5.25%次氯酸钠（NaOCl）和Qmix在不同时间间隔（2、5和10分钟）对感染根管的消毒效果。210颗单根下颌前磨牙经化学机械预备并感染。将测试样本分别暴露于CAP等离子体射流、5.25% NaOCl和Qmix中2、5和10分钟。收集根管中残留的细菌（如有），并评估其菌落形成单位（CFU）的生长情况。采用方差分析和Tukey检验评估各治疗组之间的显著差异。在暴露时间为2分钟和10分钟时，与除Qmix外的所有其他测试组相比，5.25% NaOCl显示出显著更高的抗菌效果（<0.001）。建议与5.25% NaOCl的最短接触时间为5分钟，以使感染根管中细菌生长为零。QMix需要最短接触时间10分钟才能实现最佳的CFU减少，而CAP等离子体射流需要最短接触时间5分钟才能实现显著的CFU减少。
