人类11号染色体q23带区基因的定位研究与表达
Mapping studies and expression of genes located on human chromosome 11, band q23.
作者信息
Savage P D, Jones C, Silver J, Geurts van Kessel A H, Gonzalez-Sarmiento R, Palm L, Hanson C A, Kersey J H
机构信息
Department of Medicine, University of Minnesota Hospital and Clinic, Minneapolis 55455.
出版信息
Cytogenet Cell Genet. 1988;49(4):289-92. doi: 10.1159/000132680.
Chromosome translocations and deletions may alter cellular proto-oncogenes and result in cellular changes that are important in the pathogenesis of malignancy. The region 11q23 is frequently involved in human malignancy. Utilizing a leukemic cell line with a reciprocal translocation involving 11q23 and somatic cell hybrids derived from this cell line, we analyzed five genes assigned to 11q23: NCAM, CD3D, CD3E, THY1, and ETS1. Our data showed no evidence of direct involvement of these genes in this leukemia but enabled a partial genetic map of this important region of the human genome to be constructed: 11cen--NCAM--CD3([G, D], E)--parallel--(ETS1, THY1)--11qter.
染色体易位和缺失可能会改变细胞原癌基因，并导致细胞发生变化，这些变化在恶性肿瘤的发病机制中具有重要意义。11q23区域经常与人类恶性肿瘤相关。利用一种具有涉及11q23的相互易位的白血病细胞系以及由此细胞系衍生的体细胞杂种，我们分析了定位于11q23的五个基因：神经细胞黏附分子（NCAM）、CD3D、CD3E、胸腺细胞抗原1（THY1）和ETS1。我们的数据没有显示这些基因直接参与这种白血病的证据，但能够构建人类基因组这一重要区域的部分遗传图谱：11号染色体着丝粒——NCAM——CD3（[G，D]，E）——平行——（ETS1，THY1）——11q末端。
Zotero 插件