意大利伦巴第地区帕金森病患者的 COVID-19 状况。
COVID-19 in Parkinson's Disease Patients Living in Lombardy, Italy.
机构信息
Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, UHN, Division of Neurology, University of Toronto, Toronto, Ontario, Canada.
Krembil Brain Institute, Toronto, Ontario, Canada.
出版信息
Mov Disord. 2020 Jul;35(7):1089-1093. doi: 10.1002/mds.28176. Epub 2020 Jun 26.
BACKGROUND
It is unknown whether patients with PD are at greater risk of COVID-19, what their risk factors are, and whether their clinical manifestations differ from the general population.
OBJECTIVES
The study aimed to address all these issues.
METHODS
In a case-controlled survey, we interviewed 1,486 PD patients attending a single tertiary center in Lombardy, Italy and 1,207 family members (controls).
RESULTS
One hundred five (7.1%) and 92 controls (7.6%) were identified as COVID-19 cases. COVID-19 patients were younger, more likely to suffer from chronic obstructive pulmonary disease, to be obese, and vitamin D nonsupplemented than unaffected patients. Six patients (5.7%) and 7 family members (7.6%) died from COVID-19. Patients were less likely to report shortness of breath and require hospitalization.
CONCLUSIONS
In an unselected large cohort of nonadvanced PD patients, COVID-19 risk and mortality did not differ from the general population, but symptoms appeared to be milder. The possible protective role of vitamin D supplementation warrants future studies. © 2020 International Parkinson and Movement Disorder Society.
背景
目前尚不清楚帕金森病患者是否面临更大的 COVID-19 风险、其风险因素有哪些，以及他们的临床表现是否与普通人群不同。
目的
本研究旨在解决所有这些问题。
方法
在一项病例对照调查中，我们采访了意大利伦巴第地区的一家三级中心的 1486 名帕金森病患者和 1207 名家属（对照组）。
结果
105 名（7.1%）和 92 名对照（7.6%）被确定为 COVID-19 病例。与未受影响的患者相比，COVID-19 患者更年轻、更易患慢性阻塞性肺疾病、肥胖和维生素 D 缺乏。6 名患者（5.7%）和 7 名家属（7.6%）死于 COVID-19。患者出现呼吸急促和需要住院治疗的情况较少。
结论
在一项未经选择的非晚期帕金森病患者大队列中，COVID-19 的风险和死亡率与普通人群没有差异，但症状似乎较轻。维生素 D 补充可能具有保护作用，值得进一步研究。© 2020 国际帕金森病和运动障碍协会。
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