Otolaryngology, Head and Neck Department, Minia University Hospital, 122 Kornish El-Neel Street, Minia City, Minia, Egypt.
Am J Otolaryngol. 2020 Jul-Aug;41(4):102344. doi: 10.1016/j.amjoto.2019.102344. Epub 2019 Nov 12.
Recurrent tonsillitis in children is a common disease affecting children quality of life and extends to their families. The aim of this study was to assess the effect of combined use of oral Azithromycin (AZT) plus Echinacea compared to exclusive use of AZT in children with recurrent tonsillitis.
A prospective comparative study including three groups of children with recurrent tonsillitis. Group 1: (100 patients) had no prophylactic treatment. Group 2 (100 patients) received [60 mg/kg] prophylactic dose of AZT divided as (10 mg/kg/day) over 6 consecutive days every month for 6 consecutive months. Group 3 (100 patients) received AZT as in group 2 plus commercially available Echinacea in a dose of 5 ml oral suspension; 3 times daily for 10 consecutive days every month for 6 consecutive months. Number of tonsillitis attacks and severity of tonsillitis symptoms were assessed and compared in different groups.
Group 2 and group 3 had significant less number of tonsillitis attacks and severity of assessed symptoms during 6 months of prophylactic treatment with significant better results in group 3 (i.e. AZT plus Echinacea) compared to group 2 (I.e. AZT alone). However; there was no significant difference in patients with any prophylaxis.
The combined use of Echinacea with Azithromycin produced favorable outcome than Azithromycin alone in pediatric patients with recurrent tonsillitis.
儿童复发性扁桃体炎是一种常见疾病,影响儿童的生活质量,并延伸到他们的家庭。本研究旨在评估口服阿奇霉素(AZT)联合紫锥菊与单独使用 AZT 治疗儿童复发性扁桃体炎的效果。
这是一项前瞻性比较研究,包括三组复发性扁桃体炎患儿。第 1 组(100 例)未进行预防治疗。第 2 组(100 例)接受 [60mg/kg] 预防性 AZT 剂量,分为(10mg/kg/天),连续 6 天,每月一次,连续 6 个月。第 3 组(100 例)接受与第 2 组相同的 AZT 治疗,外加市售紫锥菊,剂量为 5ml 口服混悬液;每日 3 次,每月连续 10 天,连续 6 个月。评估并比较不同组中扁桃体炎发作次数和严重程度。
第 2 组和第 3 组在 6 个月的预防治疗中扁桃体炎发作次数和评估症状严重程度明显减少,第 3 组(即 AZT 加紫锥菊)的效果明显优于第 2 组(即 AZT 单独使用)。然而,在任何预防措施中,患者之间均无显著差异。
在儿童复发性扁桃体炎患者中,紫锥菊联合阿奇霉素的使用比单独使用阿奇霉素产生了更好的效果。