El Hennawi Diaa El Din Mohamed, Rifaat Ahmed Mohamed
Otolaryngology Unit, Faculty of Medicine, Suez Canal University , Ismailia, Egypt.
Interv Med Appl Sci. 2016 Dec;8(4):141-146. doi: 10.1556/1646.8.2016.4.2.
Recurrent tonsillitis is a common disease with marked evidence of affecting children quality of life (QOL) such as their progression in school and increased burden to extended families. The aim of this study was to compare the QOL outcomes after conventional dissection tonsillectomy versus azithromycin treatment in controlling recurrent tonsillitis.
A double-blind, randomized clinical trial was carried out in 184 children with recurrent tonsillitis randomly divided into two groups: Group A was subjected to conventional dissection tonsillectomy, whereas Group B received single 250 mg (children ≤25 kg) and 500 mg (children ≥25 kg) of oral azithromycin once weekly.
There were no significant differences between the groups with regard to ear, nose, and throat infections during the 5-year follow-up. Better QOL was observed in both groups when compared with the pretreatment, but similar QOL in both groups QOL after treatment.
Azithromycin is an effective method as a prophylaxis against recurrent tonsillitis with a great benefit for better QOL outcomes.
复发性扁桃体炎是一种常见疾病，有明显证据表明它会影响儿童的生活质量（QOL），比如影响他们的学业进展以及增加大家庭的负担。本研究的目的是比较传统扁桃体切除术与阿奇霉素治疗在控制复发性扁桃体炎方面的生活质量结果。
对184例复发性扁桃体炎患儿进行了一项双盲随机临床试验，这些患儿被随机分为两组：A组接受传统扁桃体切除术，而B组每周口服一次250毫克（25千克及以下儿童）和500毫克（25千克以上儿童）阿奇霉素。
在5年随访期间，两组在耳、鼻、喉感染方面无显著差异。与治疗前相比，两组的生活质量均有所改善，但治疗后两组的生活质量相似。
阿奇霉素是预防复发性扁桃体炎的有效方法，对改善生活质量有很大益处。
