Laboratory of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan
Laboratory of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba, Japan.
Anticancer Res. 2020 Jun;40(6):3271-3276. doi: 10.21873/anticanres.14309.
BACKGROUND/AIM: This study aimed to determine the anxiolytic effect of a putative glyoxalase 1 inhibitor, piceatannol, as well as its antitumor activities on the stress-induced tumor growth of Lewis lung carcinoma.
The anxiolytic activities of piceatannol (1-30 mg/kg) were assessed using the elevated plus maze (EPM) test. We also evaluated the pharmacological modulation of stress-induced tumor growth; the mice were treated with piceatannol (3 and 30 mg/kg) from the 10 day till the 19 day after administration of the LLC cells.
At the low dose (3 mg/kg), piceatannol significantly increased the time spent in the open arms of the EPM test when compared with the vehicle. At higher doses (30 mg/kg), it significantly suppressed the stress-induced enhancement of tumor growth.
A low dose of piceatannol exerts an anxiolytic effect, and high doses have an antitumor effect.
背景/目的：本研究旨在确定一种潜在的糖氧物酶 1 抑制剂白藜芦醇对应激诱导的 Lewis 肺癌肿瘤生长的抗焦虑作用及其抗肿瘤活性。
使用高架十字迷宫（EPM）试验评估白藜芦醇（1-30mg/kg）的抗焦虑活性。我们还评估了应激诱导肿瘤生长的药物调节；用白藜芦醇（3 和 30mg/kg）从 LLC 细胞给药后的第 10 天到第 19 天进行治疗。
低剂量（3mg/kg）时，白藜芦醇与载体相比，显著增加了 EPM 测试中开放臂的停留时间。高剂量（30mg/kg）时，它显著抑制了应激诱导的肿瘤生长增强。
低剂量的白藜芦醇具有抗焦虑作用，高剂量具有抗肿瘤作用。
