Yoshizawa Kazumi, Kurono Ruka, Sato Haruka, Ishijima Erika, Nasu Haruka, Ferdaos Nurfarhana, Suzuki Hidetaka, Negishi Kenichi
Laboratory of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences,Tokyo University of Science, Chiba, Japan.
Department of Pharmacology and Chemistry, Faculty of Pharmacy,Universiti Teknologi MARA, Selangor, Malaysia.
Cancer Diagn Progn. 2021 May 3;1(2):95-102. doi: 10.21873/cdp.10014. eCollection 2021 May-Jun.
BACKGROUND/AIM: Fatigue is the most common symptom in patients with cancer undergoing radiation therapy or cancer chemotherapy. However, cancer-related fatigue remains undertreated and poorly understood.
Mice were administered a single dose of cisplatin (10 mg/kg, intraperitoneally) or saline (as a control) and then treated with sucrose, fructose, glucose (each at 500 or 5,000 mg/kg, orally), or saline (control) daily for 4 days. cisplatin-induced fatigue-like behavior was investigated by assessment of running activity on a treadmill. The influence of glucose intake on tumor growth was also examined in Lewis lung carcinoma (LLC)-bearing mice.
Administration of sucrose and glucose improved cisplatin-induced fatigue-like behavior in mice, whereas administration of fructose showed only slight antifatigue effects. Although glucose-fed mice showed increased tumor growth, this was balanced out by the powerful cytotoxicity of cisplatin.
Sucrose, and especially glucose, may improve patient quality of life during treatment with anticancer agents by preventing fatigue without interfering with the antitumor effects of cisplatin.
背景/目的：疲劳是接受放射治疗或癌症化疗的癌症患者最常见的症状。然而，癌症相关疲劳仍未得到充分治疗且了解不足。
给小鼠腹腔注射单剂量顺铂（10毫克/千克）或生理盐水（作为对照），然后每天口服蔗糖、果糖、葡萄糖（各500或5000毫克/千克）或生理盐水（对照），持续4天。通过评估跑步机上的跑步活动来研究顺铂诱导的疲劳样行为。还在携带Lewis肺癌（LLC）的小鼠中研究了葡萄糖摄入对肿瘤生长的影响。
给予蔗糖和葡萄糖可改善顺铂诱导的小鼠疲劳样行为，而给予果糖仅显示出轻微的抗疲劳作用。尽管喂食葡萄糖的小鼠肿瘤生长增加，但顺铂强大的细胞毒性抵消了这一影响。
蔗糖，尤其是葡萄糖，可能通过预防疲劳而不干扰顺铂的抗肿瘤作用，来改善抗癌药物治疗期间患者的生活质量。
