Shichiri M, Yamasaki Y, Nao K, Sekiya M, Ueda N
Department of Metabolic Medicine, Kumamoto University Medical School, Japan.
Horm Metab Res Suppl. 1988;20:17-20.
To explore the clinical performances of the needle-type glucose sensor, in vivo monitoring was conducted in human subjects. The tissue glucose concentrations measured by glucose sensor were lower than the plasma glucose concentrations by 15%, but a good linear relationship was observed between the tissue and plasma glucose concentrations. The sensing sites between abdomen and forearm did not affect the tissue glucose monitoring. The tissue glucose concentrations after meal intake showed 5 min delayed response to the blood glucose concentrations. After 3 days' continuous monitoring, the "relative" sensor output to the plasma glucose concentration decreased by 26% and the "relative" response time to reach peak value prolonged from 5 min to 13.5 min. These data indicate the clinical usefulness of the needle-type glucose sensor.
为探究针型葡萄糖传感器的临床性能，在人体受试者中进行了体内监测。葡萄糖传感器测得的组织葡萄糖浓度比血浆葡萄糖浓度低15%，但组织与血浆葡萄糖浓度之间观察到良好的线性关系。腹部和前臂的传感部位不影响组织葡萄糖监测。进食后组织葡萄糖浓度对血糖浓度的反应延迟5分钟。连续监测3天后，传感器对血浆葡萄糖浓度的“相对”输出降低了26%，达到峰值的“相对”响应时间从5分钟延长至13.5分钟。这些数据表明针型葡萄糖传感器具有临床实用性。
