人格与抑郁症状：10项队列研究的个体参与者荟萃分析

PERSONALITY AND DEPRESSIVE SYMPTOMS: INDIVIDUAL PARTICIPANT META-ANALYSIS OF 10 COHORT STUDIES.

作者信息

Hakulinen Christian, Elovainio Marko, Pulkki-Råback Laura, Virtanen Marianna, Kivimäki Mika, Jokela Markus

机构信息

Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.

National Institute for Health and Welfare, Helsinki, Finland.

出版信息

Depress Anxiety. 2015 Jul;32(7):461-70. doi: 10.1002/da.22376. Epub 2015 May 26.

DOI:10.1002/da.22376

PMID:26014798

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4605994/

Abstract

BACKGROUND

Personality is suggested to be a major risk factor for depression but large-scale individual participant meta-analyses on this topic are lacking.

METHOD

Data from 10 prospective community cohort studies with 117,899 participants (mean age 49.0 years; 54.7% women) were pooled for individual participant meta-analysis to determine the association between personality traits of the five-factor model and risk of depressive symptoms.

RESULTS

In cross-sectional analysis, low extraversion (pooled standardized regression coefficient (B) = -.08; 95% confidence interval = -0.11, -0.04), high neuroticism (B = .39; 0.32, 0.45), and low conscientiousness (B = -.09; -0.10, -0.06) were associated with depressive symptoms. Similar associations were observed in longitudinal analyses adjusted for baseline depressive symptoms (n = 56,735; mean follow-up of 5.0 years): low extraversion (B = -.03; -0.05, -0.01), high neuroticism (B = .12; 0.10, 0.13), and low conscientiousness (B = -.04; -0.06, -0.02) were associated with an increased risk of depressive symptoms at follow-up. In turn, depressive symptoms were associated with personality change in extraversion (B = -.07; 95% CI = -0.12, -0.02), neuroticism (B = .23; 0.09, 0.36), agreeableness (B = -.09; -0.15, -0.04), conscientiousness (B = -.14; -0.21, -0.07), and openness to experience (B = -.04; -0.08, 0.00).

CONCLUSIONS

Personality traits are prospectively associated with the development of depressive symptoms. Depressive symptoms, in turn, are associated with changes in personality that may be temporary or persistent.

摘要

背景

人格被认为是抑郁症的一个主要风险因素，但缺乏关于该主题的大规模个体参与者荟萃分析。

方法

汇总来自10项前瞻性社区队列研究的数据，共117,899名参与者（平均年龄49.0岁；54.7%为女性）进行个体参与者荟萃分析，以确定五因素模型的人格特质与抑郁症状风险之间的关联。

结果

在横断面分析中，低外向性（合并标准化回归系数（B）= -0.08；95%置信区间= -0.11，-0.04）、高神经质（B = 0.39；0.32，0.45）和低尽责性（B = -0.09；-0.10，-0.06）与抑郁症状相关。在对基线抑郁症状进行调整的纵向分析中（n = 56,735；平均随访5.0年）观察到类似的关联：低外向性（B = -0.03；-0.05，-0.01）、高神经质（B = 0.12；0.10，0.13）和低尽责性（B = -0.04；-0.06，-0.02）与随访时抑郁症状风险增加相关。反过来，抑郁症状与外向性（B = -0.07；95%CI = -0.12，-0.02）、神经质（B = 0.23；0.09，0.36）、宜人性（B = -0.09；-0.15，-0.04）、尽责性（B = -0.14；-0.21，-0.07）和开放性（B = -0.04；-0.08，0.00）的人格变化相关。